Practical one-pot syntheses of ethyl 4-substituted-1H-pyrrole-3-carboxylates from aldehydes

被引：11

作者：

Chang, Jay Hyok ^{[1
]}

Shin, Hyunik ^{[1
]}

机构：

[1] LG Life Sci Ltd R&D, Chem Dev Div, Taejon 305380, South Korea

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 02期

关键词：

D O I：

10.1021/op7002826

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Ethyl 4-substituted-1H-pyrrole-3-carboxylates were prepared in a one-pot manner starting from aromatic or aliphatic aldehydes via a Horner-Wadsworth-Emmons reaction and subsequent reaction with tosylmethylisocyanide (TosMIC) in the presence of sodium tert-amylate in toluene. Judicious selection of base and solvent led to the use of a single solvent, i.e., toluene, for reactions as well as for crystallization to render the one-pot process more practical and greener than the stepwise version.

引用

页码：291 / 293

页数：3

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