The Effect of Toll-Like Receptor 4 on Macrophage Cytokines During Endotoxin Induced Uveitis

被引：14
|
作者：
Yang, Shuo [1 ]
Lu, Hong [1 ]
Wang, Jing [1 ]
Qi, Xin [1 ]
Liu, Xuhui [1 ]
Zhang, Xiaolong [1 ]
机构：
[1] Capital Med Univ, Chaoyang Hosp, Dept Ophthalmol, Beijing 100020, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 06期
关键词：
Toll-like receptor 4; mice peritoneal macrophage; endotoxin-induced uveitis; cytokine; DENDRITIC CELLS; ALTERNATIVE ACTIVATION; CUTTING EDGE; EXPRESSION; LIPOPOLYSACCHARIDE; IL-10; MICE; IMMUNITY; COMPLEX; ANTIGEN;
D O I：
10.3390/ijms13067508
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Toll-like receptor 4 (TLR4) signal activation of macrophages can lead to endotoxin-induced uveitis (EIU). Previously, our research group has demonstrated a higher expression of TLR4 in vivo during EIU than normal. In this study, we analyzed levels of peritoneal macrophage cytokines from C3H/HeN mice with LPS stimulation in vitro to elucidate the effect of TLR4 on cytokines during EIU.
引用
收藏
页码：7508 / 7520
页数：13
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