An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

被引：77

作者：

Boedhoe, Premika S. W. ^{[1
,2
]}

Heymans, Martijn W. ^{[3
]}

Schmaal, Lianne ^{[4
,5
]}

Abe, Yoshinari ^{[6
]}

Alonso, Pino ^{[7
,8
,9
]}

Ameis, Stephanie H. ^{[10
,11
]}

Anticevic, Alan ^{[12
]}

Arnold, Paul D. ^{[13
,14
]}

Batistuzzo, Marcelo C. ^{[15
]}

Benedetti, Francesco ^{[16
]}

Beucke, Jan C. ^{[17
]}

Bollettini, Irene ^{[16
]}

Bose, Anushree ^{[18
]}

Brem, Silvia ^{[19
]}

Calvo, Anna ^{[20
]}

Calvo, Rosa ^{[8
,21
]}

Cheng, Yuqi ^{[22
]}

Cho, Kang lk K. ^{[23
]}

Ciullo, Valentina ^{[24
,25
]}

Dallaspezia, Sara ^{[16
]}

Denys, Damiaan ^{[26
,27
]}

Feusner, Jamie D. ^{[28
]}

Fitzgerald, Kate D. ^{[29
]}

Fouches, Jean-Paul ^{[30
]}

Fridgeirsson, Egill A. ^{[26
]}

Gruner, Patricia ^{[12
]}

Henna, Gregory L. ^{[29
]}

Hibar, Derrek P. ^{[31
]}

Hoexter, Marcelo Q. ^{[15
]}

Hu, Hao ^{[32
]}

Huyser, Chaim ^{[33
,34
]}

Jahanshad, Neda ^{[35
]}

James, Anthony ^{[36
]}

Kathmann, Norbert ^{[17
]}

Kaufmann, Christian ^{[17
]}

Koch, Kathrin ^{[37
,38
]}

Kwon, Jun Soo ^{[39
,40
]}

Lazaro, Luisa ^{[8
,21
,41
,42
]}

Lochner, Christine ^{[43
]}

Marsh, Rachel ^{[44
,45
]}

Martinez-Zalacain, Ignacio ^{[7
]}

Mataix-Cols, David ^{[46
]}

Menchon, Jose M. ^{[7
,8
,9
]}

Minuzzi, Luciano ^{[47
]}

Morer, Astrid ^{[8
,21
,41
]}

Nakamae, Takashi ^{[6
]}

Nakao, Tomohiro ^{[48
]}

Narayanaswamy, Janardhanan C. ^{[18
]}

Nishida, Seiji ^{[6
]}

Nurmi, Erika L. ^{[28
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr UMC, Amsterdam Neurosci, Dept Psychiat, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr UMC, Amsterdam Neurosci, Dept Anat & Neurosci, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Orygen, Melbourne, Vic, Australia

[5] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[6] Kyoto Prefectural Univ Med, Dept Psychiat, Grad Sch Med Sci, Kyoto, Japan

[7] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Barcelona, Spain

[8] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain

[9] Univ Barcelona, Dept Clin Sci, Barcelona, Spain

[10] Univ Toronto, Campbell Family Mental Hlth Res Inst, Margaret & Wallace McCain Ctr Child Youth & Famil, Fac Med,Ctr Addict & Mental Hlth,Dept Psychiat, Toronto, ON, Canada

[11] Hosp Sick Children, Ctr Brain & Mental Hlth, Toronto, ON, Canada

[12] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[13] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Cumming Sch Med, Hotchkiss Brain Inst, Calgary, AB, Canada

[14] Univ Calgary, Cumming Sch Med, Dept Psychiat, Calgary, AB, Canada

[15] Univ Sao Paulo, Fac Med, Inst Psiquiatria, Dept Psiquiatria, Sao Paulo, Brazil

[16] Sci Inst Osped San Raffaele, Div Neurosci Psychiat & Clin Psychobiol, Milan, Italy

[17] Humboldt Univ, Dept Psychol, Berlin, Germany

[18] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Obsess Compuls Disorder OCD Clin, Bangalore, Karnataka, India

[19] Univ Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

[20] IDIBAPS, Magnet Resonance Image Core Facil, Barcelona, Spain

[21] Hosp Clin Univ, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain

[22] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China

[23] SNU MRC, Inst Human Behav Med, Seoul, South Korea

[24] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy

[25] Univ Florence, Neurosci Psychol Drug Res & Chid Hlth NEUROFARBA, Florence, Italy

[26] Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Dept Psychiat, Amsterdam, Netherlands

[27] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam, Netherlands

[28] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[29] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[30] Univ Cape Town, Dept Psychiat, MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa

[31] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA

[32] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China

[33] De Bascule, Acad Ctr Child & Adolescent Psychiat, Amsterdam, Netherlands

[34] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Child & Adolescent Psychiat, Amsterdam, Netherlands

[35] Seoul Natl Univ, Yeongeon Student Support Ctr, Coll Med, Seoul, South Korea

[36] Univ Oxford, Dept Psychiat, Oxford, England

[37] Tech Univ Munich, Dept Neuroradiol, Klinikum Rechts Isar, Munich, Germany

[38] Tech Univ Munich, TUM Neuroimeging Ctr TUM NIC, Klinikum Rechts Isar, Munich, Germany

[39] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea

[40] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea

[41] IDIBAPS, Barcelona, Spain

[42] Univ Barcelona, Dept Med, Barcelona, Spain

[43] Univ Stellenbosch, UCT MRC Unit Anxiety & Stress Disorders, Dept Psychiat, Stellenbosch, South Africa

[44] Columbia Univ, Med Coll, New York, NY USA

[45] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[46] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden

[47] St Josephs HealthCare, Mood Disorders Clin, Hamilton, ON, Canada

[48] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Fukuoka, Japan

[49] AIR Brain Informat Commun Res Lab Grp, Kyoto, Japan

[50] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, Brazil

来源：

FRONTIERS IN NEUROINFORMATICS | 2019年 / 12卷

基金：

瑞士国家科学基金会; 英国惠康基金;

关键词：

neuroimaging; MRI; IPD meta-analysis; mega-analysis; linear mixed-effect models; CEREBRAL-CORTEX; METAANALYSIS; SIZE; ASSOCIATION; EFFICIENCY; VARIANCE; MODELS; BRAIN; OCD; MRI;

D O I：

10.3389/fninf.2018.00102

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.

引用

页数：8

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