An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

被引:67
作者
Boedhoe, Premika S. W. [1 ,2 ]
Heymans, Martijn W. [3 ]
Schmaal, Lianne [4 ,5 ]
Abe, Yoshinari [6 ]
Alonso, Pino [7 ,8 ,9 ]
Ameis, Stephanie H. [10 ,11 ]
Anticevic, Alan [12 ]
Arnold, Paul D. [13 ,14 ]
Batistuzzo, Marcelo C. [15 ]
Benedetti, Francesco [16 ]
Beucke, Jan C. [17 ]
Bollettini, Irene [16 ]
Bose, Anushree [18 ]
Brem, Silvia [19 ]
Calvo, Anna [20 ]
Calvo, Rosa [8 ,21 ]
Cheng, Yuqi [22 ]
Cho, Kang lk K. [23 ]
Ciullo, Valentina [24 ,25 ]
Dallaspezia, Sara [16 ]
Denys, Damiaan [26 ,27 ]
Feusner, Jamie D. [28 ]
Fitzgerald, Kate D. [29 ]
Fouches, Jean-Paul [30 ]
Fridgeirsson, Egill A. [26 ]
Gruner, Patricia [12 ]
Henna, Gregory L. [29 ]
Hibar, Derrek P. [31 ]
Hoexter, Marcelo Q. [15 ]
Hu, Hao [32 ]
Huyser, Chaim [33 ,34 ]
Jahanshad, Neda [35 ]
James, Anthony [36 ]
Kathmann, Norbert [17 ]
Kaufmann, Christian [17 ]
Koch, Kathrin [37 ,38 ]
Kwon, Jun Soo [39 ,40 ]
Lazaro, Luisa [8 ,21 ,41 ,42 ]
Lochner, Christine [43 ]
Marsh, Rachel [44 ,45 ]
Martinez-Zalacain, Ignacio [7 ]
Mataix-Cols, David [46 ]
Menchon, Jose M. [7 ,8 ,9 ]
Minuzzi, Luciano [47 ]
Morer, Astrid [8 ,21 ,41 ]
Nakamae, Takashi [6 ]
Nakao, Tomohiro [48 ]
Narayanaswamy, Janardhanan C. [18 ]
Nishida, Seiji [6 ]
Nurmi, Erika L. [28 ]
机构
[1] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr UMC, Amsterdam Neurosci, Dept Psychiat, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr UMC, Amsterdam Neurosci, Dept Anat & Neurosci, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands
[4] Orygen, Melbourne, Vic, Australia
[5] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
[6] Kyoto Prefectural Univ Med, Dept Psychiat, Grad Sch Med Sci, Kyoto, Japan
[7] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Barcelona, Spain
[8] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain
[9] Univ Barcelona, Dept Clin Sci, Barcelona, Spain
[10] Univ Toronto, Campbell Family Mental Hlth Res Inst, Margaret & Wallace McCain Ctr Child Youth & Famil, Fac Med,Ctr Addict & Mental Hlth,Dept Psychiat, Toronto, ON, Canada
[11] Hosp Sick Children, Ctr Brain & Mental Hlth, Toronto, ON, Canada
[12] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[13] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Cumming Sch Med, Hotchkiss Brain Inst, Calgary, AB, Canada
[14] Univ Calgary, Cumming Sch Med, Dept Psychiat, Calgary, AB, Canada
[15] Univ Sao Paulo, Fac Med, Inst Psiquiatria, Dept Psiquiatria, Sao Paulo, Brazil
[16] Sci Inst Osped San Raffaele, Div Neurosci Psychiat & Clin Psychobiol, Milan, Italy
[17] Humboldt Univ, Dept Psychol, Berlin, Germany
[18] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Obsess Compuls Disorder OCD Clin, Bangalore, Karnataka, India
[19] Univ Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland
[20] IDIBAPS, Magnet Resonance Image Core Facil, Barcelona, Spain
[21] Hosp Clin Univ, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
[22] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China
[23] SNU MRC, Inst Human Behav Med, Seoul, South Korea
[24] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy
[25] Univ Florence, Neurosci Psychol Drug Res & Chid Hlth NEUROFARBA, Florence, Italy
[26] Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Dept Psychiat, Amsterdam, Netherlands
[27] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam, Netherlands
[28] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
[29] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
[30] Univ Cape Town, Dept Psychiat, MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
[31] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA
[32] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
[33] De Bascule, Acad Ctr Child & Adolescent Psychiat, Amsterdam, Netherlands
[34] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Child & Adolescent Psychiat, Amsterdam, Netherlands
[35] Seoul Natl Univ, Yeongeon Student Support Ctr, Coll Med, Seoul, South Korea
[36] Univ Oxford, Dept Psychiat, Oxford, England
[37] Tech Univ Munich, Dept Neuroradiol, Klinikum Rechts Isar, Munich, Germany
[38] Tech Univ Munich, TUM Neuroimeging Ctr TUM NIC, Klinikum Rechts Isar, Munich, Germany
[39] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
[40] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea
[41] IDIBAPS, Barcelona, Spain
[42] Univ Barcelona, Dept Med, Barcelona, Spain
[43] Univ Stellenbosch, UCT MRC Unit Anxiety & Stress Disorders, Dept Psychiat, Stellenbosch, South Africa
[44] Columbia Univ, Med Coll, New York, NY USA
[45] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[46] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden
[47] St Josephs HealthCare, Mood Disorders Clin, Hamilton, ON, Canada
[48] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Fukuoka, Japan
[49] AIR Brain Informat Commun Res Lab Grp, Kyoto, Japan
[50] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, Brazil
来源
FRONTIERS IN NEUROINFORMATICS | 2019年 / 12卷
基金
英国惠康基金; 瑞士国家科学基金会;
关键词
neuroimaging; MRI; IPD meta-analysis; mega-analysis; linear mixed-effect models; CEREBRAL-CORTEX; METAANALYSIS; SIZE; ASSOCIATION; EFFICIENCY; VARIANCE; MODELS; BRAIN; OCD; MRI;
D O I
10.3389/fninf.2018.00102
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.
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页数:8
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共 29 条
  • [1] Agresti A, 2000, STAT MED, V19, P1115, DOI 10.1002/(SICI)1097-0258(20000430)19:8<1115::AID-SIM408>3.3.CO
  • [2] 2-O
  • [3] Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Barnes, Josephine
    Ridgway, Gerard R.
    Bartlett, Jonathan
    Henley, Susie M. D.
    Lehmann, Manja
    Hobbs, Nicola
    Clarkson, Matthew J.
    MacManus, David G.
    Ourselin, Sebastien
    Fox, Nick C.
    [J]. NEUROIMAGE, 2010, 53 (04) : 1244 - 1255
  • [4] Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
    Boedhoe, Premika S. W.
    Schmaal, Lianne
    Abe, Yoshinari
    Alonso, Pino
    Ameis, Stephanie H.
    Anticevic, Alan
    Arnold, Paul D.
    Batistuzzo, Marcelo C.
    Benedetti, Francesco
    Beucke, Jan C.
    Bollettini, Irene
    Bose, Anushree
    Brem, Silvia
    Calvo, Anna
    Calvo, Rosa
    Cheng, Yuqi
    Cho, Kang Ik K.
    Ciullo, Valentina
    Dallaspezia, Sara
    Denys, Damiaan
    Feusner, Jamie D.
    Fitzgerald, Kate D.
    Fouche, Jean-Paul
    Fridgeirsson, Egill A.
    Gruner, Patricia
    Hanna, Gregory L.
    Hibar, Derrek P.
    Hoexter, Marcelo Q.
    Hu, Hao
    Huyser, Chaim
    Jahanshad, Neda
    James, Anthony
    Kathmann, Norbert
    Kaufmann, Christian
    Koch, Kathrin
    Kwon, Jun Soo
    Lazaro, Luisa
    Lochner, Christine
    Marsh, Rachel
    Martinez-Zalacain, Ignacio
    Mataix-Cols, David
    Menchon, Jose M.
    Minuzzi, Luciano
    Morer, Astrid
    Nakamae, Takashi
    Nakao, Tomohiro
    Narayanaswamy, Janardhanan C.
    Nishida, Seiji
    Nurmi, Erika
    O'Neill, Joseph
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2018, 175 (05) : 453 - 462
  • [5] Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al.
    Boedhoe, Premika S. W.
    Schmaal, Lianne
    Mataix-Cols, David
    Jahanshad, Neda
    Thompson, Paul M.
    Stein, Dan
    van den Heuvel, Odile A.
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2017, 174 (06) : 597 - 599
  • [6] Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
    Boedhoe, Premika S. W.
    Schmaal, Lianne
    Abe, Yoshinari
    Ameis, Stephanie H.
    Arnold, Paul D.
    Batistuzzo, Marcelo C.
    Benedetti, Francesco
    Beucke, Jan C.
    Bollettini, Irene
    Bose, Anushree
    Brem, Silvia
    Calvo, Anna
    Cheng, Yuqi
    Cho, Kang Ik K.
    Dallaspezia, Sara
    Denys, Damiaan
    Fitzgerald, Kate D.
    Fouche, Jean-Paul
    Gimenez, Monica
    Gruner, Patricia
    Hanna, Gregory L.
    Hibar, Derrek P.
    Hoexter, Marcelo Q.
    Hu, Hao
    Huyser, Chaim
    Ikari, Keisuke
    Jahanshad, Neda
    Kathmann, Norbert
    Kaufmann, Christian
    Koch, Kathrin
    Kwon, Jun Soo
    Lazaro, Luisa
    Liu, Yanni
    Lochner, Christine
    Marsh, Rachel
    Martinez-Zalacain, Ignacio
    Mataix-Cols, David
    Menchon, Jose M.
    Minuzzi, Luciano
    Nakamae, Takashi
    Nakao, Tomohiro
    Narayanaswamy, Janardhanan C.
    Piras, Fabrizio
    Piras, Federica
    Pittenger, Christopher
    Reddy, Y. C. Janardhan
    Sato, Joao R.
    Simpson, H. Blair
    Soreni, Noam
    Soriano-Mas, Caries
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2017, 174 (01) : 60 - 69
  • [7] A basic introduction to fixed-effect and random-effects models for meta-analysis
    Borenstein, Michael
    Hedges, Larry V.
    Higgins, Julian P. T.
    Rothstein, Hannah R.
    [J]. RESEARCH SYNTHESIS METHODS, 2010, 1 (02) : 97 - 111
  • [8] Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ
    Burke, Danielle L.
    Ensor, Joie
    Riley, Richard D.
    [J]. STATISTICS IN MEDICINE, 2017, 36 (05) : 855 - 875
  • [9] Practical aspects of imputation-driven meta-analysis of genome-wide association studies
    de Bakker, Paul I. W.
    Ferreira, Manuel A. R.
    Jia, Xiaoming
    Neale, Benjamin M.
    Raychaudhuri, Soumya
    Voight, Benjamin F.
    [J]. HUMAN MOLECULAR GENETICS, 2008, 17 : R122 - R128
  • [10] Individual Participant Data Meta-Analysis for a Binary Outcome: One-Stage or Two-Stage?
    Debray, Thomas P. A.
    Moons, Karel G. M.
    Abo-Zaid, Ghada Mohammed Abdallah
    Koffijberg, Hendrik
    Riley, Richard David
    [J]. PLOS ONE, 2013, 8 (04):