Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups

被引：25

作者：

Acker, Carmine Ines ^{[1
]}

Guerra Souza, Ana Cristina ^{[1
]}

Pinton, Simone ^{[1
]}

da Rocha, Juliana Trevisan ^{[1
]}

Friggi, Caroline Amaral ^{[2
]}

Zanella, Renato ^{[2
]}

Nogueira, Cristina Wayne ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, Ctr Ciencias Nat & Exatas, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Dept Quim, LARP Lab Anal Residuos Pesticidas, BR-97105900 Santa Maria, RS, Brazil

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2011年 / 74卷 / 08期

关键词：

Pesticides; Malathion; AChE activity; Behavior; Rat pups; ORGANOPHOSPHATE PESTICIDES; COLORIMETRIC DETERMINATION; CHLORPYRIFOS EXPOSURE; ACETYLCHOLINESTERASE; TOXICITY; ATPASE; NEUROTOXICITY; NICOTINE; DEFICITS;

D O I：

10.1016/j.ecoenv.2011.07.035

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na+ K+ ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200 mg/kg) orally (p.o.), once a day for four consecutive days. Rat pups were submitted to behavioral tests on the 5th day, 24 h after the last malathion administration. Malathion at the dose of 200 mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2310 / 2315

页数：6

共 41 条

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