Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex

被引：57
作者：
Doidge, Rachel [1 ,2 ]
Mittal, Saloni [1 ,2 ]
Aslam, Akhmed [1 ,2 ]
Winkler, G. Sebastiaan [1 ,2 ]
机构：
[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
[2] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
BTG/Tob; Ccr4-Not complex; deadenylase; mRNA processing; mRNA decay; ribonuclease; TRANSCRIPTION FACTOR; STRUCTURAL BASIS; PROTEIN; CAF1; REGULATOR; MECHANISM; TOB; IDENTIFICATION; TRANSLATION; DEGRADATION;
D O I：
10.1042/BST20120074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Ccr4-Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease-exonuclease-phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins.
引用
收藏
页码：896 / 901
页数：6
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