Real-world non-interventional long-term post-authorisation safety study of ruxolitinib in myelofibrosis

Primary objective of this non-interventional, post-authorisation safety study was to provide real-world safety data [incidence of adverse drug reactions (ADRs)/serious adverse events (SAEs)] on adult patients with myelofibrosis exposed/or not exposed to ruxolitinib. Key secondary objectives included the incidence/outcome of events of special interest (bleeding events, serious/opportunistic infections, second primary malignancies, and deaths). Overall, 462 patients were included [prevalent users = 260, new users = 32, non-exposed = 170 (inclusive of ruxolitinib-switch,n = 57)]. The exposure-adjusted incidence rates (per 100 patient-years) of ADRs (19 center dot 3 vs. 19 center dot 6) and SAEs (25 center dot 2 vs. 25 center dot 0) were comparable amongst new-usersversusprevalent-users cohorts, respectively; most frequent ADRs across all cohorts included thrombocytopenia, anaemia, epistaxis, urinary tract infection, and herpes zoster. Anaemia, pneumonia, general physical health deterioration, sepsis, and death were the most frequent SAEs across all cohorts. Incidence rates of bleeding events (21 center dot 6) and serious/opportunistic infections (34 center dot 5) were higher in ruxolitinib-switch cohortversusother cohorts. The incidence rate of second primary malignancies was higher in the prevalent-users cohort (10 center dot 1)versusother cohorts. The observed safety profile of ruxolitinib in the present study along with the safety findings from the COMFORT/JUMP/EXPAND studies support the use of ruxolitinib for long-term treatment of patients with myelofibrosis.