Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration

被引：13

作者：

Li, Tianyou ^{[1
,2
]}

Chen, Song ^{[3
]}

Pei, Ming ^{[1
,4
]}

机构：

[1] West Virginia Univ, Dept Orthopaed, Stem Cell & Tissue Engn Lab, 64 Med Ctr Dr,POB 9196, Morgantown, WV 26506 USA

[2] Shandong First Med Univ, Shandong Prov Hosp, Dept Pediat Orthopaed, Jinan, Peoples R China

[3] Gen Hosp Western Theater Command, Dept Orthopaed, Chengdu 610083, Sichuan, Peoples R China

[4] West Virginia Univ, Robert C Byrd Hlth Sci Ctr, WVU Canc Inst, Morgantown, WV 26506 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 23期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Neural crest-derived cells; Mesoderm-derived cells; Cartilage regeneration; Stem cells; Nasal chondrocytes; Articular chondrocytes; DOUBLE MUTATIONS; SYNOVIAL JOINTS; ROOF PLATE; HUMAN KNEE; TISSUE; DEFECTS; MATRIX; DIFFERENTIATION; GASTRULATION; SINGLE;

D O I：

10.1007/s00018-020-03567-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to poor self-regenerative potential of articular cartilage, stem cell-based regeneration becomes a hopeful approach for the treatment of articular cartilage defects. Recent studies indicate that neural crest-derived cells (NCDCs) have the potential for repairing articular cartilage with even greater chondrogenic capacity than mesoderm-derived cells (MDCs): a conventional stem cell source for cartilage regeneration. Given that NCDCs originate from a different germ layer in the early embryo compared with MDCs that give rise to articular cartilage, a mystery remains regarding their capacity for articular cartilage regeneration. In this review, we summarize the similarities and differences between MDCs and NCDCs including articular and nasal chondrocytes in cell origin, anatomy, and chondrogenic differentiation and propose that NCDCs might be promising cell origins for articular cartilage regeneration.

引用

页码：4847 / 4859

页数：13

共 95 条

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