Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase

被引：6
|
作者：
Yu, Tengfei [1 ]
Guan, Yuepeng [2 ]
Xie, Xia [3 ]
Huang, Yaqin [2 ]
Tang, Jie [4 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Nanlou Clin Div, Dept Ultrasound, Beijing 100853, Peoples R China
[2] Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
[3] Tsinghua Univ, Dept Ultrasound, Beijing Tsinghua Changgung Hosp, Med Ctr, Beijing 102218, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Ultrasound, Beijing 100853, Peoples R China
来源：
INTERNATIONAL JOURNAL OF POLYMER SCIENCE | 2015年 / 2015卷
关键词：
SPONGE; COMBINATION; RELEASE; MATRIX;
D O I：
10.1155/2015/985286
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
It is well known that the thrombin obtained from animal is available in clinical treatment, which plays an important role in hemostasis and the treatment of hemorrhagic diseases. However, how to achieve complete hemostasis in 2 min is still a challenge. In this report, the thrombin hemostatic has been improved using the cross-linked gelatin by microbial transglutaminase, and its efficacy was demonstrated by the vitro experiment. Compared with the traditional thrombin hemostatic the clotting time with the improved hemostat is significantly shorter. It may rapidly stop blood loss, which would provide a simple, safe, and cost-effective surgical sealant.
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页数：4
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