Anti-inflammatory activity of Jatropha curcas roots in mice and rats

被引：71

作者：

Mujumdar, AM ^{[1
]}

Misar, A ^{[1
]}

机构：

[1] Agharkar Res Inst, Pune 411004, Maharashtra, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 01期

关键词：

Jatropha curcas L. roots; Albino rats and mice; local and systemic anti-inflammatory activity;

D O I：

10.1016/j.jep.2003.09.019

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-inflammatory activity of topical application of Jatropha curcas L. root powder in paste form in TPA-induced ear inflammation was confirmed in albino mice and the successive solvent extraction of these roots was carried out by ether and methanol. The methanol extract exhibited systemic and significant anti-inflammatory activity in acute carrageenan-induced rat paw. edema. It also showed activity against formalin-induced rat paw edema, as well as, turpentine-induced exudative changes and cotton pellet-induced granular tissue formation after oral treatment for 7 days in albino rats. Thus, resultant anti-inflammatory activity might be due to effects on several mediators and arachidonic acid metabolism involving cyclo-oxygenase pathway resulting in prostaglandin formation, anti-proliferative activity leading to reduction in granular tissue formation and leukocyte migration from the vessels. (C) 2003 Published by Elsevier Ireland Ltd.

引用

页码：11 / 15

页数：5

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