The promise of cytokine antibody arrays in the drug discovery process

被引:23
作者
Huang, RP
Yang, WM
Yang, DZ
Flowers, L
Horowitz, IR
Cao, X
Huang, RC
机构
[1] Emory Univ, Sch Med, Div Res, Dept Gynecol & Obstet, Atlanta, GA 30322 USA
[2] Sun Yat Sen Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
关键词
antibody array; cytokine; drug discovery; protein array;
D O I
10.1517/14728222.9.3.601
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The introduction of cytokine antibody arrays has added a new approach for investigators to simultaneously measure multiple cytokine levels in biological samples. Several different platforms have been developed. The ability to measure hundreds of cytokine levels with high specificity and sensitivity within a very limited amount of samples is a powerful tool. Many investigators worldwide have applied this novel technology in their biomedical research, particularly in drug discovery. Undoubtedly, the technology will continue to be improved and the application increased in the next several years.
引用
收藏
页码:601 / 615
页数:15
相关论文
共 83 条
[1]   Targeting cytokines in autoimmunity: new approaches, new promise [J].
Andreakos, E .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2003, 3 (03) :435-447
[2]   Cytokines and anti-cytokine biologicals in autoimmunity: present and future [J].
Andreakos, ET ;
Foxwell, BM ;
Brennan, FM ;
Maini, RN ;
Feldmann, M .
CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (4-5) :299-313
[3]  
BALKWILL FR, 1994, EUR CYTOKINE NETW, V5, P379
[4]   Angiogenesis in epithelian ovarian cancer [J].
Bamberger, ES ;
Perrett, CW .
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 2002, 55 (06) :348-359
[5]   Hematopoiesis and cytokines - Relevance to cancer and aging [J].
Baraldi-Junkins, CA ;
Beck, AC ;
Rothstein, G .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2000, 14 (01) :45-+
[6]   Cytokine-directed therapies for the treatment of chronic airway diseases [J].
Barnes, PJ .
CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (06) :511-522
[7]   Photoaptamer arrays applied to multiplexed proteomic analysis [J].
Bock, C ;
Coleman, M ;
Collins, B ;
Davis, J ;
Foulds, G ;
Gold, L ;
Greef, C ;
Heil, J ;
Heilig, JS ;
Hicke, B ;
Hurst, MN ;
Husar, GM ;
Miller, D ;
Ostroff, R ;
Petach, H ;
Schneider, D ;
Vant-Hull, B ;
Waugh, S ;
Weiss, A ;
Wilcox, SK ;
Zichi, D .
PROTEOMICS, 2004, 4 (03) :609-618
[8]   A cytokine profile of normal and malignant ovary [J].
Burke, F ;
Relf, M ;
Negus, R ;
Balkwill, F .
CYTOKINE, 1996, 8 (07) :578-585
[9]   Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay [J].
Carson, RT ;
Vignali, DAA .
JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 227 (1-2) :41-52
[10]   Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment -: A novel resource for biomarker and therapeutic target discovery [J].
Celis, JE ;
Gromov, P ;
Cabezón, T ;
Moreira, JMA ;
Ambartsumian, N ;
Sandelin, K ;
Rank, F ;
Gromova, I .
MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (04) :327-344