Collagen-chitosan composite membranes controlled transdermal delivery of nifedipine and propranolol hydrochloride

被引：20

作者：

Thacharodi, D ^{[1
]}

Rao, KP ^{[1
]}

机构：

[1] CENT LEATHER RES INST,DIV BIOMAT,MADRAS 600020,TAMIL NADU,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 134卷 / 1-2期

关键词：

collagen-chitosan composite membrane; nifedipine; propranolol hydrochloride; transdermal delivery;

D O I：

10.1016/0378-5173(96)04453-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Membrane-permeation-controlled transdermal devices were fabricated for the controlled delivery of nifedipine and propranolol hydrochloride using composite membranes made of natural polymers chitosan and collagen. Devices were fabricated for a single application daily. The drug release profiles from these devices were evaluated in modified Franz glass diffusion cells using rabbit pinna skin. The data showed that the devices effectively controlled the transdermal delivery of both drugs.

引用

页码：239 / 241

页数：3

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