Future strategies for the treatment of atraumatic femoral head necrosis

被引：0

作者：

Noeth, U. ^{[1
]}

Reppenhagen, S. ^{[1
]}

Steinert, A. ^{[1
]}

Jakob, F. ^{[1
]}

Reichert, J. ^{[1
]}

Rudert, M. ^{[1
]}

Rackwitz, L. ^{[1
]}

机构：

[1] Univ Wurzburg, Leitender Oberarzt Sekt Endoprothet Regenerat Med, Orthopad Klin, Lehrstuhl Orthopadie, D-97074 Wurzburg, Germany

来源：

OSTEOLOGIE | 2010年 / 19卷 / 01期

关键词：

Femoral head necrosis; stem cells; growth factors; osteochondral transplantation; autologous chondrocyte transplantation (ACT); MESENCHYMAL STEM-CELLS; COLONY-STIMULATING FACTOR; ENDOTHELIAL GROWTH-FACTOR; AVASCULAR NECROSIS; BONE; OSTEONECROSIS; DIFFERENTIATION; HIP; TRANSPLANTATION; COMBINATION;

D O I：

暂无

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Early stages of atraumatic femoral head necrosis (ARCO stage I and II) with preserved structural integrity of the subchondral plate are accessible for retrograde conducted surgical procedures, such as core decompression, to induce bone remodelling. The additive application of bone marrow aspirates, ex vivo expanded bone marrow stem cells, as well as osteogenic or angiogenic growth factors has the potential to improve bone regeneration. Whereas, advanced stages of atraumatic femoral head necrosis with a collapsed subchondral plate (ARCO stage III) require an osteochondral reconstruction to preserve the physiological joint function without the need of total joint replacement. In analogy to strategies for osteochondral reconstruction in the knee joint, transplantation of autologous osteochondral cylinders or matrix-based autologous chondrocyte transplantation, might preserve the joint function in the future.

引用

页码：53 / 59

页数：7

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