Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

被引：57
作者：
Zhang, Yongxin [1 ]
Fu, Hao [1 ]
Chen, Shuai [1 ]
Liu, Bingqing [2 ]
Sun, Wenfang [2 ]
Gao, Hui [1 ]
机构：
[1] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin Key Lab Drug Targeting & Bioimaging, Tianjin Key Lab Organ Solar Cells & Photochem Con, Tianjin 300384, Peoples R China
[2] North Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 05期
基金：
中国国家自然科学基金;
关键词：
PHOTOSENSITIZER; RELEASE;
D O I：
10.1039/c9cc09357e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal-organic framework (MOF), a biscyclometalated iridium(iii) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.
引用
收藏
页码：762 / 765
页数：4
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