Lucky Number Seven: RNase 7 Can Prevent Staphylococcus aureus Skin Colonization

被引：11

作者：

Cho, John S. ^{[1
]}

Xuan, Caiyun ^{[1
]}

Miller, Lloyd S. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Hlth Sci 52 121, Ctr Hlth Sci,Div Dermatol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 12期

关键词：

HYPER-IGE SYNDROME; SOFT-TISSUE INFECTIONS; INNATE IMMUNE-RESPONSE; ANTIMICROBIAL PEPTIDES; ATOPIC-DERMATITIS; HUMAN BETA-DEFENSIN-3; TH17; CELLS; EXPRESSION; PROTECTS; MUTATIONS;

D O I：

10.1038/jid.2010.294

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Staphylococcus aureus colonization is a major risk factor for infection. In this issue, Simanski et al. demonstrate that the antimicrobial peptide RNase 7 is essential for preventing S. aureus colonization in human skin. These findings suggest that therapeutic interventions aimed at targeting RNase 7 production in the skin may be a novel strategy to protect against S. aureus infections.

引用

页码：2703 / 2706

页数：5

共 29 条

[1] Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus [J].

Bode, Lonneke G. M. ;

Kluytmans, Jan A. J. W. ;

Wertheim, Heiman F. L. ;

Bogaers, Diana ;

Vandenbroucke-Grauls, Christina M. J. E. ;

Roosendaal, Robert ;

Troelstra, Annet ;

Box, Adrienne T. A. ;

Voss, Andreas ;

van der Tweel, Ingeborg ;

van Belkum, Alex ;

Verbrugh, Henri A. ;

Vos, Margreet C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (01) :9-17

[2] Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens [J].

Braff, MH ;

Zaiou, M ;

Fierer, J ;

Nizet, V ;

Gallo, RL .

INFECTION AND IMMUNITY, 2005, 73 (10) :6771-6781

[3] IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice [J].

Cho, John S. ;

Pietras, Eric M. ;

Garcia, Nairy C. ;

Ramos, Romela Irene ;

Farzam, David M. ;

Monroe, Holly R. ;

Magorien, Julie E. ;

Blauvelt, Andrew ;

Kolls, Jay K. ;

Cheung, Ambrose L. ;

Cheng, Genhong ;

Modlin, Robert L. ;

Miller, Lloyd S. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1762-1773

[4] Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis [J].

Darouiche, Rabih O. ;

Wall, Matthew J., Jr. ;

Itani, Kamal M. F. ;

Otterson, Mary F. ;

Webb, Alexandra L. ;

Carrick, Matthew M. ;

Miller, Harold J. ;

Awad, Samir S. ;

Crosby, Cynthia T. ;

Mosier, Michael C. ;

AlSharif, Atef ;

Berger, David H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (01) :18-26

[5] Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus [J].

Daum, Robert S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (04) :380-390

[6] Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection [J].

Gläser, R ;

Harder, J ;

Lange, H ;

Bartels, J ;

Christophers, E ;

Schröder, JM .

NATURE IMMUNOLOGY, 2005, 6 (01) :57-64

[7] A US population-based survey of Staphylococcus aureus colonization [J].

Graham, PL ;

Lin, SX ;

Larson, EL .

ANNALS OF INTERNAL MEDICINE, 2006, 144 (05) :318-325

[8] RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin [J].

Harder, J ;

Schröder, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :46779-46784

[9] Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic [J].

Harder, J ;

Bartels, J ;

Christophers, E ;

Schröder, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5707-5713

[10] A peptide antibiotic from human skin [J].

Harder, J ;

Bartels, J ;

Christophers, E ;

Schroder, JM .

NATURE, 1997, 387 (6636) :861-861

← 1 2 3 →