Neural plate patterning: Upstream and downstream of the isthmic organizer

被引：428

作者：

Wurst, W

Bally-Cuif, L

机构：

[1] GSF, Res Ctr, Inst Mammalian Genet, D-85764 Neuherberg, Germany

[2] Max Planck Inst Psychiat, D-80809H Munich, Germany

[3] Tech Univ Munich, Zebrafish Neurogenet Res Grp, D-81675 Munich, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2001年 / 2卷 / 02期

关键词：

D O I：

10.1038/35053516

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two organizing centres operate at long-range distances within the anterior neural plate to pattern the forebrain, midbrain and hindbrain. important progress has been made in understanding the formation and function of one of these organizing centres, the isthmic organizer, which controls the development of the midbrain and anterior hindbrain. Here we review our current knowledge on the identity, localization and maintenance of the isthmic organizer, as well as on the molecular cascades that underlie the activity of this organizing centre.

引用

页码：99 / 108

页数：10

共 101 条

[1]

Acampora D, 1998, DEVELOPMENT, V125, P5091

[2]

Acampora D, 1997, DEVELOPMENT, V124, P3639

[3]

Adams KA, 2000, DEVELOPMENT, V127, P1857

[4] DEVELOPMENT OF THE BRAIN-STEM IN THE RAT .5. THYMIDINE-RADIOGRAPHIC STUDY OF THE TIME OF ORIGIN OF NEURONS IN THE MIDBRAIN TEGMENTUM [J].