Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study

被引：15

作者：

Takahashi, Tsutomu ^{[1
,12
]}

Tsugawa, Sakiko ^{[2
]}

Nakajima, Shinichiro ^{[2
]}

Plitman, Eric ^{[3
,9
,10
]}

Chakravarty, M. Mallar ^{[3
,9
,10
]}

Masuda, Fumi ^{[2
]}

Wada, Masataka ^{[2
]}

Kurose, Shin ^{[2
]}

Ochi, Ryo ^{[4
]}

Matsushita, Karin ^{[4
]}

Sasabayashi, Daiki ^{[1
]}

Nakamura, Mihoko ^{[1
]}

Nishikawa, Yumiko ^{[1
]}

Takayanagi, Yoichiro ^{[1
,5
]}

Nishiyama, Shimako ^{[1
,6
]}

Higuchi, Yuko ^{[1
]}

Mizukami, Yuko ^{[1
]}

Furuichi, Atsushi ^{[1
]}

Kido, Mikio ^{[1
]}

Hashimoto, Ryota ^{[7
,11
]}

Noguchi, Kyo ^{[8
]}

Fujii, Shinya

Mimura, Masaru ^{[2
]}

Noda, Yoshihiro ^{[2
]}

Suzuki, Michio ^{[1
]}

机构：

[1] Univ Toyama Sch Med, Dept Neuropsychiat, Toyama, Japan

[2] Keio Univ Sch Med, Dept Neuropsychiat, Tokyo, Japan

[3] Douglas Inst, Cerebral Imaging Ctr, Computat Brain Anat Lab, Verdun, PQ, Canada

[4] Keio Univ, Fac Environm, Informat Studies, Tokyo, Japan

[5] Arisawabashi Hosp, Toyama, Japan

[6] Univ Toyama, Ctr Hlth Care & Human Sci, Toyama, Japan

[7] Natl Inst Mental Hlth, Natl Ctr Neurol & Psychiat, Dept Pathol Mental Dis, Tokyo, Japan

[8] Univ Toyama Grad Sch Med & Pharmaceut Sci, Dept Radiol, Toyama, Japan

[9] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[10] McGill Univ, Dept Biol & Biomed Engn, Montreal, PQ, Canada

[11] Osaka Univ Grad Sch Med, Dept Psychiat, Suita, Japan

[12] Univ Toyama Sch Med, Dept Neuropsychiat, 2630 Sugitani, Toyama 9300194, Japan

来源：

SCHIZOPHRENIA RESEARCH | 2022年 / 243卷

关键词：

Thalamus; Medial dorsal nucleus; Ventral lateral nucleus; Magnetic resonance imaging; At-risk mental state; Schizophrenia; ULTRA-HIGH-RISK; NUCLEUS; ABNORMALITIES; HIPPOCAMPUS; COGNITION; ACCURATE; AMYGDALA; ANXIETY; SCALE; MRI;

D O I：

10.1016/j.schres.2020.04.016

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Despite previous neuroimaging studies demonstrating morphological abnormalities of the thalamus and other subcortical structures in patients with schizophrenia, the potential role of the thalamus and its subdivisions in the pathophysiology of this illness remains elusive. It is also unclear whether similar changes of these structures occur in individuals at high risk for psychosis. In this study, magnetic resonance imaging was employed with the Multiple Automatically Generated Templates (MAGeT) brain segmentation algorithm to determine volumes of the thalamic subdivisions, the striatum (caudate, putamen, and nucleus accumbens), and the globus pallidus in 62 patients with schizophrenia, 38 individuals with an at-risk mental state (ARMS) [4 of whom (10.5%) subsequently developed schizophrenia], and 61 healthy subjects. Cognitive function of the patients was assessed by using the Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Thalamic volume (particularly the medial dorsal and ventral lateral nuclei) was smaller in the schizophrenia group than the ARMS and control groups, while there were no differences for the striatum and globus pallidus. In the schizophrenia group, the reduction of thalamic ventral lateral nucleus volume was significantly associated with lower BACS score. The pallidal volume was positively correlated with the dose of antipsychotic treatment in the schizophrenia group. These results suggest that patients with schizophrenia, but not those with ARMS, exhibit volume reduction in specific thalamic subdivisions, which may underlie core clinical features of this illness.(c) 2020 Elsevier B.V. All rights reserved.

引用

页码：268 / 275

页数：8

共 72 条

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