Effects of oligonol on the submandibular gland in ovariectomized rats

被引：6

作者：

Kim, Jeong Hun ^{[1
]}

Lee, Hyangkyu ^{[2
]}

Kim, Ji Min ^{[3
]}

Kim, Hyung-Sik ^{[4
]}

Shin, Sung-Chan ^{[5
]}

Hwang, Sun-Kyung ^{[6
]}

Lee, Byung-Joo ^{[1
,5
]}

Kim, Keunyoung ^{[1
,7
]}

机构：

[1] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 49241, South Korea

[2] Yonsei Univ, Coll Nursing, Moim Kim Nursing Res Inst, Seoul 03722, South Korea

[3] Pusan Natl Univ, Sch Med, Med Res Inst, Yangsan 50612, South Korea

[4] Pusan Natl Univ, Sch Dent, Dept Life Sci Dent, Yangsan 50612, South Korea

[5] Pusan Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Busan 49241, South Korea

[6] Pusan Natl Univ, Coll Nursing, Yangsan 50612, South Korea

[7] Pusan Natl Univ Hosp, Dept Nucl Med, Busan 49241, South Korea

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷

基金：

新加坡国家研究基金会;

关键词：

Aquaporin; Oligonol; Ovariectomy; Submandibular gland; Xerostomia; OXIDATIVE STRESS; SALIVARY FLOW; LYCHEE FRUIT; EXPRESSION; MENOPAUSE; LOCALIZATION; DYSFUNCTION; AQUAPORINS; XEROSTOMIA;

D O I：

10.1016/j.biopha.2021.111897

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this study was to observe the effects of oligonol on submandibular gland dysfunction in ovariectomized rats. We randomly divided female Sprague-Dawley rats into sham-operated, ovariectomized, and oligonoltreated ovariectomized groups. Oligonol was intraperitoneally administered at 30 mg/kg daily for six weeks. Lipogenesis increased after the ovariectomy while fatty acid oxidation increased and intracellular triglyceride levels decreased in response to oligonol treatment. Submandibular gland fibrosis characterized by collagen type I accumulation was observed in the ovariectomized group. However, oligonol markedly reduced fibrosis to a level comparable to that observed in the sham group. Aquaporin 1 and glucose transporter 4 were downregulated in the ovariectomized group. Nevertheless, both factors were significantly upregulated by oligonol treatment. However, aquaporin 5 was significantly downregulated in the oligonol treatment group. Our findings indicate that oligonol protects against damage in postmenopausal rat salivary glands.

引用

页数：9

共 37 条

[1] Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland [J].