Anti-inflammatory effect of Atorvastatin (80 mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction

被引：45

作者：

Correia, LCL

Spósito, AC

Lima, JC

Magalhaes, LP

Passos, LCS

Rocha, MS

D'Oliveira, A

Esteves, JP

机构：

[1] Univ Fed Bahia, Sch Med, PhD Program, Salvador, BA, Brazil

[2] Univ Sao Paulo, Sch Med, InCor, Inst Heart, Sao Paulo, Brazil

[3] Portuguese Hosp, Div Cardiol, Salvador, BA, Brazil

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(03)00630-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non-ST-elevation acute coronary syndromes. (C)2003 by Excerpta Medica, Inc.

引用

收藏

页码：298 / 301

页数：4

相关论文

共 17 条

[1] Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes [J].

Alaei, P ;

MacNulty, EE ;

Ryder, NS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 222 (01) :133-138

[2] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study [J].

Albert, MA ;

Danielson, E ;

Rifai, N ;

Ridker, PM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01) :64-70

[3] Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability [J].

Biasucci, LM ;

Liuzzo, G ;

Grillo, RL ;

Caligiuri, G ;

Rebuzzi, AG ;

Buffon, A ;

Summaria, F ;

Ginnetti, F ;

Fadda, G ;

Maseri, A .

CIRCULATION, 1999, 99 (07) :855-860

[4] Effects of atorvastatin 80 mg daily early after onset of unstable angina pectoris or non-Q-wave myocardial infarction [J].

Colivicchi, F ;

Guido, V ;

Tubaro, M ;

Ammirati, F ;

Montefoschi, N ;

Varveri, A ;

Santini, M .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (08) :872-+

[5] Short-term effect of atorvastatin (80 mg) on plasma lipids of patients with unstable angina pectoris or non-q-wave acute myocardial infarction [J].

Correia, LCL ;

Spósito, AC ;

Passos, LCS ;

Lima, JC ;

Braga, JC ;

Rocha, MS ;

Esteves, JP ;

D'Oliveira, A .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (02) :162-+

[6] Independent prognostic value of elevated C-reactive protein in unstable angina [J].

Ferreirós, ER ;

Boissonnet, CP ;

Pizarro, R ;

Merletti, PFG ;

Corrado, G ;

Cagide, A ;

Bazzino, OO .

CIRCULATION, 1999, 100 (19) :1958-1963

[7] Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina [J].

Liuzzo, G ;

Buffon, A ;

Biasucci, LM ;

Gallimore, JR ;

Caligiuri, G ;

Vitelli, A ;

Altamura, S ;

Ciliberto, G ;

Rebuzzi, AG ;

Crea, F ;

Pepys, MB ;

Maseri, A .

CIRCULATION, 1998, 98 (22) :2370-2376

[8] C-reactive protein and other markers of inflammation among patients undergoing HELP LDL apheresis [J].

Moriarty, PM ;

Gibson, CA ;

Shih, J ;

Matias, MS .

ATHEROSCLEROSIS, 2001, 158 (02) :495-498

[9] Statins and the acute-phase response [J].

Munford, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (26) :2016-2018

[10] Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis [J].

Ni, WH ;

Egashira, K ;

Kataoka, C ;

Kitamoto, S ;

Koyanagi, M ;

Inoue, S ;

Takeshita, A .

CIRCULATION RESEARCH, 2001, 89 (05) :415-421