Treatment of pharyngeal non-Hodgkin lymphoma in a patient with Wiskott-Aldrich syndrome

被引：11

作者：

Coccia, Paola

Mastrangelo, Stefano ^{[1
]}

Ruggiero, Antonio

Scalzone, Maria

Rosolen, Angelo ^{[2
]}

Maurizi, Palma

Riccardi, Riccardo

机构：

[1] Univ Cattolica Sacro Cuore, Div Pediat Oncol, Dept Pediat Sci, I-00168 Rome, Italy

[2] Univ Hosp Padova, Pediat Oncohematol Unit, Padua, Italy

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 02期

关键词：

lymphoma; prognosis; treatment; Wiskott-Aldrich syndrome; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDREN; IMMUNODEFICIENCIES; DISEASE; CANCER; WASP;

D O I：

10.1002/pbc.23393

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wiskott-Aldrich syndrome (WAS) is characterized by primary immunodeficiency, thrombocytopenia and eczema. Patients with WAS have an increased risk to develop tumors. Non-Hodgkin lymphoma (NHL) represents the most common malignancy occurring in WAS-affected patients, diffuse-large-B-cell lymphoma is the most frequently encountered variant. We describe a case of a patient with WAS and NHL in the pharynx, an atypical tumor site presentation. The patient was successfully treated with a reduced dose chemotherapy regimen plus anti-CD20 monoclonal antibody. He is in complete remission 3 years from the start of treatment. Pediatr Blood Cancer 2012;59:318319. (c) 2011 Wiley Periodicals, Inc.

引用

页码：318 / 319

页数：2

共 16 条

[1]

ALDRICH RA, 1954, PEDIATRICS, V13, P133

[2] Improved cure rate in children with B-cell acute lymphoblastic leukaemia (B-ALL) and stage IV B-cell non Hodgkin's lymphoma (B-NHL) - results of the UKCCSG 9003 protocol [J].