Activins and inhibins in mammalian testis development: New models, new insights

被引：34

作者：

Barakat, B. ^{[2
]}

Itman, C. ^{[3
]}

Mendis, S. H. ^{[2
]}

Loveland, K. L. ^{[1
,3
]}

机构：

[1] Monash Univ, Sch Biomed Sci, Dept Anat & Dev Biol, Clayton, Vic 3880, Australia

[2] Monash Univ, Monash Inst Reprod & Dev, Clayton, Vic 3880, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3880, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 359卷 / 1-2期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Spermatogenesis; Activin; Inhibin; Cell signalling; Testis development; GONADOTROPIN-RELEASING-HORMONE; TESTICULAR PERITUBULAR CELLS; MALE GERM-CELLS; SERTOLI-CELLS; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; DIFFERENTIAL EXPRESSION; RECEPTOR ACTIVATION; TUMOR PROGRESSION; BETA SUPERFAMILY;

D O I：

10.1016/j.mce.2012.02.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of activin and inhibins as modulators of the hypothalamic-pituitary-gonadal axis has set the foundation for understanding their central importance to many facets of development and disease. This review contains an overview of the processes and cell types that are central to testis development and spermatogenesis and then provides an update focussed on information gathered over the past five years to address new concepts about how these proteins function to control testis development in fetal and juvenile life. Current knowledge about the interactive nature of the transforming growth factor-beta (TGF beta) superfamily signalling network is applied to recent findings about activins and inhibins in the testis. Information about the regulated synthesis of signalling components and signalling regulators in the testis is integrated with new concepts that demonstrate their functional significance. The importance of activin bioactivity levels or dosage in controlling balanced growth of spermatogonial cells and their niche at different stages of testis development is highlighted. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：66 / 77

页数：12

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