Hepatotoxicity of pyrrolizidine alkaloids in rats in relation to human exposure

被引:4
作者
Bolt, Hermann M. [1 ]
机构
[1] Leibniz Res Ctr Working Environm & Human Factors, Ardeystr 67, D-44139 Dortmund, Germany
关键词
PRIMARY HEPATOCYTES; PLANTS;
D O I
10.1007/s00204-020-02850-y
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
引用
收藏
页码:2885 / 2886
页数:2
相关论文
共 22 条
[1]  
BfR, 2018, AKT RIS GEH 1 2 UNG, P1
[2]  
BfR, 2019, PYRR GETR TIEFG GEW
[3]   Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey [J].
Bodi, Dorina ;
Ronczka, Stefan ;
Gottschalk, Christoph ;
Behr, Nastassja ;
Skibba, Anne ;
Wagner, Matthias ;
Lahrssen-Wiederholt, Monika ;
Preiss-Weigert, Angelika ;
These, Anja .
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2014, 31 (11) :1886-1895
[4]   Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study [J].
Ebmeyer, Johanna ;
Rasinger, Josef Daniel ;
Hengstler, Jan G. ;
Schaudien, Dirk ;
Creutzenberg, Otto ;
Lampen, Alfonso ;
Braeuning, Albert ;
Hessel-Pras, Stefanie .
ARCHIVES OF TOXICOLOGY, 2020, 94 (05) :1739-1751
[5]   Influence of Liver Fibrosis on Lobular Zonation [J].
Ghallab, Ahmed ;
Myllys, Maiju ;
Holland, Christian H. ;
Zaza, Ayham ;
Murad, Walaa ;
Hassan, Reham ;
Ahmed, Yasser A. ;
Abbas, Tahany ;
Abdelrahim, Eman A. ;
Schneider, Kai Markus ;
Matz-Soja, Madlen ;
Reinders, Joerg ;
Gebhardt, Rolf ;
Berres, Marie-Luise ;
Hatting, Maximilian ;
Drasdo, Dirk ;
Saez-Rodriguez, Julio ;
Trautwein, Christian ;
Hengstler, Jan G. .
CELLS, 2019, 8 (12)
[6]   Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood [J].
Ghallab, Ahmed ;
Hofmann, Ute ;
Sezgin, Selahaddin ;
Vartak, Nachiket ;
Hassan, Reham ;
Zaza, Ayham ;
Godoy, Patricio ;
Schneider, Kai Markus ;
Guenther, Georgia ;
Ahmed, Yasser A. ;
Abbas, Aya A. ;
Keitel, Verena ;
Kuepfer, Lars ;
Dooley, Steven ;
Lammert, Frank ;
Trautwein, Christian ;
Spiteller, Michael ;
Drasdo, Dirk ;
Hofmann, Alan F. ;
Jansen, Peter L. M. ;
Hengstler, Jan G. ;
Reif, Raymond .
HEPATOLOGY, 2019, 69 (02) :666-683
[7]   Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases [J].
Ghallab, Ahmed ;
Celliere, Geraldine ;
Henkel, Sebastian G. ;
Driesch, Dominik ;
Hoehme, Stefan ;
Hofmann, Ute ;
Zellmer, Sebastian ;
Godoy, Patricio ;
Sachinidis, Agapios ;
Blaszkewicz, Meinolf ;
Reif, Raymond ;
Marchan, Rosemarie ;
Kuepfer, Lars ;
Haeussinger, Dieter ;
Drasdo, Dirk ;
Gebhardt, Rolf ;
Hengstler, Jan G. .
JOURNAL OF HEPATOLOGY, 2016, 64 (04) :860-871
[8]   Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue [J].
Godoy, Patricio ;
Widera, Agata ;
Schmidt-Heck, Wolfgang ;
Campos, Gisela ;
Meyer, Christoph ;
Cadenas, Cristina ;
Reif, Raymond ;
Stoeber, Regina ;
Hammad, Seddik ;
Puetter, Larissa ;
Gianmoena, Kathrin ;
Marchan, Rosemarie ;
Ghallab, Ahmed ;
Edlund, Karolina ;
Nuessler, Andreas ;
Thasler, Wolfgang E. ;
Damm, Georg ;
Seehofer, Daniel ;
Weiss, Thomas S. ;
Dirsch, Olaf ;
Dahmen, Uta ;
Gebhardt, Rolf ;
Chaudhari, Umesh ;
Meganathan, Kesavan ;
Sachinidis, Agapios ;
Kelm, Jens ;
Hofmann, Ute ;
Zahedi, Rene P. ;
Guthke, Reinhard ;
Bluethgen, Nils ;
Dooley, Steven ;
Hengstler, Jan G. .
ARCHIVES OF TOXICOLOGY, 2016, 90 (10) :2513-2529
[9]   Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME [J].
Godoy, Patricio ;
Hewitt, Nicola J. ;
Albrecht, Ute ;
Andersen, Melvin E. ;
Ansari, Nariman ;
Bhattacharya, Sudin ;
Bode, Johannes Georg ;
Bolleyn, Jennifer ;
Borner, Christoph ;
Boettger, Jan ;
Braeuning, Albert ;
Budinsky, Robert A. ;
Burkhardt, Britta ;
Cameron, Neil R. ;
Camussi, Giovanni ;
Cho, Chong-Su ;
Choi, Yun-Jaie ;
Rowlands, J. Craig ;
Dahmen, Uta ;
Damm, Georg ;
Dirsch, Olaf ;
Teresa Donato, Maria ;
Dong, Jian ;
Dooley, Steven ;
Drasdo, Dirk ;
Eakins, Rowena ;
Ferreira, Karine Sa ;
Fonsato, Valentina ;
Fraczek, Joanna ;
Gebhardt, Rolf ;
Gibson, Andrew ;
Glanemann, Matthias ;
Goldring, Chris E. P. ;
Jose Gomez-Lechon, Maria ;
Groothuis, Geny M. M. ;
Gustavsson, Lena ;
Guyot, Christelle ;
Hallifax, David ;
Hammad, Seddik ;
Hayward, Adam ;
Haeussinger, Dieter ;
Hellerbrand, Claus ;
Hewitt, Philip ;
Hoehme, Stefan ;
Holzhuetter, Hermann-Georg ;
Houston, J. Brian ;
Hrach, Jens ;
Ito, Kiyomi ;
Jaeschke, Hartmut ;
Keitel, Verena .
ARCHIVES OF TOXICOLOGY, 2013, 87 (08) :1315-1530
[10]   Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes [J].
Grinberg, Marianna ;
Stoeber, Regina M. ;
Albrecht, Wiebke ;
Edlund, Karolina ;
Schug, Markus ;
Godoy, Patricio ;
Cadenas, Cristina ;
Marchan, Rosemarie ;
Lampen, Alfonso ;
Braeuning, Albert ;
Buhrke, Thorsten ;
Leist, Marcel ;
Oberemm, Axel ;
Hellwig, Birte ;
Kamp, Hennicke ;
Gardner, Iain ;
Escher, Sylvia ;
Taboureau, Olivier ;
Aguayo-Orozco, Alejandro ;
Sachinidis, Agapios ;
Ellinger-Ziegelbauer, Heidrun ;
Rahnenfuehrer, Joerg ;
Hengstler, Jan G. .
ARCHIVES OF TOXICOLOGY, 2018, 92 (12) :3517-3533