RNA interference in head and neck oncology

被引：2

作者：

Sobecka, Agnieszka ^{[1
,2
]}

Barczak, Wojciech ^{[1
,2
,3
]}

Suchorska, Wiktoria Maria ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Greater Poland Canc Ctr, Dept Med Phys, Garbary 15 St, PL-61866 Poznan, Poland

[2] Poznan Univ Med Sci, Greater Poland Canc Ctr, Dept Radiobiol Lab, Garbary 15 St, PL-61866 Poznan, Poland

[3] Poznan Univ Med Sci, Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland

来源：

ONCOLOGY LETTERS | 2016年 / 12卷 / 05期

关键词：

head and neck cancer; RNA interference; gene therapy; siRNA; miRNA; SQUAMOUS-CELL CARCINOMA; RESISTANCE PROTEIN BCRP/ABCG2; VIRAL VECTORS; AURORA KINASE; CANCER-CELLS; MULTIDRUG-RESISTANCE; NERVOUS-SYSTEM; TONGUE CANCER; GENE-TRANSFER; IN-VIVO;

D O I：

10.3892/ol.2016.5079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer worldwide. The treatment of choice in case of head and neck cancer is surgery, followed by chemo- or/and radiotherapy. A potentially effective instrument to improve the outcome of numerous diseases, including viral infections, diabetes and cancer, is RNA interference (RNAi). It has been demonstrated that small interfering RNA and microRNA molecules are strongly involved in the regulation of various different pathological processes in cancer development. RNAi has become a valuable research tool allowing a better understanding of the mechanisms regulating cancer pathogenesis. Considering those advantages over other current therapeutics (including specificity and high efficacy), RNAi appears to be a potentially useful tool in cancer treatment. The present review discusses the current knowledge about the possibility of using RNAi in HNSCC therapy.

引用

页码：3035 / 3040

页数：6

共 61 条

[1] RNA interference: Biology, mechanism, and applications [J].