One-pot synthesis of oxoisoindoline-1,2,3-triazole hybrid by a Ugi-click reaction

被引：10

作者：

Akrami, Sara ^{[1
]}

Firoozpour, Loghman ^{[2
]}

Goli-Garmroodi, Fereshteh ^{[3
,4
]}

Moghimi, Setareh ^{[3
,4
]}

Mahdavi, Mohammad ^{[2
]}

Zonouzi, Afsaneh ^{[1
]}

Foroumadi, Alireza ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran

[2] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

[5] Kerman Univ Med Sci, Inst Neuropharmacol, Fac Pharm, Dept Med Chem, Kerman, Iran

[6] Kerman Univ Med Sci, Inst Neuropharmacol, Neurosci Res Ctr, Kerman, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 20期

基金：

美国国家科学基金会;

关键词：

Click reaction; multicomponent reaction; one-pot synthesis; 1,2,3-triazole; Ugi reaction; MULTICOMPONENT REACTIONS; INHIBITORS; DERIVATIVES; TRANSFORMATIONS; DISCOVERY;

D O I：

10.1080/00397911.2016.1223313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields. [GRAPHICS] .

引用

收藏

页码：1708 / 1712

页数：5

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