Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

被引：119
作者：
Li, Dongyue [1 ]
Zhan, Peng [1 ]
De Clercq, Erik [2 ]
Liu, Xinyong [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Shandong, Peoples R China
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 08期
基金：
高等学校博士学科点专项科研基金; 中国博士后科学基金; 中国国家自然科学基金;
关键词：
RESISTANT MUTANT VIRUSES; MEDICINAL CHEMISTRY; DRUG CANDIDATES; MOLECULAR HYBRIDIZATION; ANGSTROM RESOLUTION; ANTIVIRAL ACTIVITY; ETRAVIRINE TMC125; BROAD POTENCY; DAPY ANALOGS; WILD-TYPE;
D O I：
10.1021/jm200990c
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：3595 / 3613
页数：19
相关论文
共 80 条
[71]  
WOLFE P, 2001, 8 C RETR OPP INF CHI
[72]   BENZOPHENONE DERIVATIVES - A NOVEL SERIES OF POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE [J].
WYATT, PG ;
BETHELL, RC ;
CAMMACK, N ;
CHARON, D ;
DODIC, N ;
DUMAITRE, B ;
EVANS, DN ;
GREEN, DVS ;
HOPEWELL, PL ;
HUMBER, DC ;
LAMONT, RB ;
ORR, DC ;
PLESTED, SJ ;
RYAN, DM ;
SOLLIS, SL ;
STORER, R ;
WEINGARTEN, GG .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1657-1665
[73]  
Yeh L., 2009, 47 INT C ANT AG CHEM
[74]   Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy [J].
Zeng, Zhao-Sen ;
He, Qiu-Qin ;
Liang, Yong-Hong ;
Feng, Xiao-Qing ;
Chen, Fen-Er ;
De Clercq, Erik ;
Balzarini, Jan ;
Pannecouque, Christophe .
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (14) :5039-5047
[75]   Lead Optimization of Diarylpyrimidines as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase [J].
Zeng, Zhao-Sen ;
Liang, Yong-Hong ;
Feng, Xiao-Qing ;
Chen, Fen-Er ;
Pannecouque, Christophe ;
Balzarini, Jan ;
De Clercq, Erik .
CHEMMEDCHEM, 2010, 5 (06) :837-840
[76]   HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design [J].
Zhan, Peng ;
Chen, Xuwang ;
Li, Dongyue ;
Fang, Zengjun ;
De Clercq, Erik ;
Liu, Xinyong .
MEDICINAL RESEARCH REVIEWS, 2013, 33 :E1-E72
[77]   A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors [J].
Zhang, Zhijun ;
Xu, Wen ;
Koh, Yung-Hyo ;
Shim, Jae Hoon ;
Girardet, Jean-Luc ;
Yeh, Li-Tain ;
Hamatake, Robert K. ;
Hong, Zhi .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (02) :429-437
[78]   Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective [J].
Zhao, Hongyu .
DRUG DISCOVERY TODAY, 2007, 12 (3-4) :149-155
[79]   Medicinal chemistry strategies in follow-on drug discovery [J].
Zhao, Hongyu ;
Guo, Zongru .
DRUG DISCOVERY TODAY, 2009, 14 (9-10) :516-522
[80]   Effect of a bound non-nucleoside RT inhibitor on the dynamics of wild-type and mutant HIV-1 reverse transcriptase [J].
Zhou, ZG ;
Madrid, M ;
Evanseck, JD ;
Madura, JD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (49) :17253-17260
12345678