Interaction of antimony(III) chloride with thiourea, 2-mercapto-5-methyl-benzimidazole, 3-methyl-2-mercaptobenzothiazole, 2-mercaptopyrimidine, and 2-mercaptopyridine

被引：29

作者：

Ozturk, I. I. ^{[1
,6
]}

Kourkoumelis, N. ^{[2
]}

Hadjikakou, S. K. ^{[1
]}

Manos, M. J. ^{[3
]}

Tasiopoulos, A. J. ^{[3
]}

Butler, I. S. ^{[4
]}

Balzarini, J. ^{[5
]}

Hadjiliadis, N. ^{[1
]}

机构：

[1] Univ Ioannina, Dept Chem, Sect Inorgan & Analyt Chem, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Sch Med, Med Phys Lab, GR-45110 Ioannina, Greece

[3] Univ Cyprus, Dept Chem, CY-1678 Nicosia, Cyprus

[4] McGill Univ, Dept Chem, Montreal, PQ H2A 2K6, Canada

[5] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[6] Namik Kemal Univ, Inorgan Chem Sect, Dept Chem, TR-59030 Tekirdag, Turkey

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2011年 / 64卷 / 22期

关键词：

Bioinorganic chemistry; Antimony(III) chloride complexes; Thioamides; Crystal structure; Cytotoxic activity; CRYSTAL-STRUCTURE; IN-VITRO; DIPHENYLANTIMONY(III) DERIVATIVES; STRUCTURAL-CHARACTERIZATION; X-RAY; COMPLEXES; THIOAMIDES; VAN;

D O I：

10.1080/00958972.2011.633603

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New antimony(III) chloride complexes with heterocyclic thioamides, thiourea (TU), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 3-methyl-2-mercaptobenzothiazole (MMBZT), 2-mercaptopyrimidine (PMT), 2-mercaptopyridine (PYT) of formulae [SbCl3(TU)(2)] (1), [SbCl3(MMBZIM)(2)] (2), [SbCl3(MMBZT)(2)] (3), [SbCl3(PMT)(2)] (4), [SbCl3(mu(2)-S)(PYT)(2)] (5) were synthesized and characterized by elemental analysis, FT-IR and FT-Raman spectroscopies, and TG-DTA analysis. The crystal structure of 5 was also determined by X-ray diffraction. [C10H10Cl3N2S2Sb] (5) crystallizes in space group C2/c, with a = 25.0169(10) angstrom, b = 9.7952(3) angstrom, c = 12.9329(5) angstrom, beta = 109.702(4)degrees, and Z = 8. Crystals of 5 grown from acetonitrile solutions adopt a square-pyramidal geometry. The equatorial plane is formed by three chlorides and one sulfur atom from the thione ligand while the second sulfur is axial. The complexes were evaluated for their biological activities and compared with [SbCl3(MMI)(2)] (6) (MMI = 2-mercapto-1-methylimidazole) and other isostructural ones. The complexes showed moderate cytostatic activity against murine leukemia cells (L1210), murine mammary carcinoma cells (FM3A), human T-lymphocyte (Molt4/C8, CEM), and human cervix carcinoma (HeLa) cells. The chloro and iodo derivatives show better cytostatic activity than the bromo ones.

引用

页码：3859 / 3871

页数：13

共 40 条

[1]

[Anonymous], J CHEM RES

[2]

[Anonymous], MAIN GROUP ELEMENTS

[3]

[Anonymous], J CHEM SOC DA

[4]

[Anonymous], PHARM BASIS THERAPEU

[5]

[Anonymous], CURR CHEMOTHER P

[6]

[Anonymous], REV INFECT DIS

[7]

[Anonymous], 2006, CRYSALIS CCD CRYSALI

[8]

[Anonymous], CRYSALIS RED VERS 1

[9]

BARA A, 1991, ANTICANCER RES, V11, P1651

[10] Van der Waals radii of elements [J].

Batsanov, SS .

INORGANIC MATERIALS, 2001, 37 (09) :871-885

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