UCSCXenaShiny: an R/CRAN package for interactive analysis of UCSC Xena data

被引：100

作者：

Wang, Shixiang ^{[1
,2
,3
]}

Xiong, Yi ^{[4
,5
,6
]}

Zhao, Longfei ^{[7
]}

Gu, Kai ^{[8
]}

Li, Yin ^{[9
]}

Zhao, Fei ^{[3
,10
]}

Li, Jianfeng ^{[11
,12
]}

Wang, Mingjie ^{[11
]}

Wang, Haitao ^{[13
]}

Tao, Ziyu ^{[1
]}

Wu, Tao ^{[1
]}

Zheng, Yichao ^{[7
]}

Li, Xuejun ^{[4
,5
]}

Liu, Xue-Song ^{[1
]}

机构：

[1] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Hunan Int Sci & Technol Cooperat Base Brain Tumor, Changsha 410008, Peoples R China

[6] Cent South Univ, Xiangya Sch Med, Changsha 410013, Peoples R China

[7] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[8] Roche Diagnost Shanghai Ltd, Shanghai 201107, Peoples R China

[9] Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, Shanghai 200032, Peoples R China

[10] CAS Ctr Excellence Mol Plant Sci, Shanghai 200032, Peoples R China

[11] Shanghai Jiao Tong Univ, Rui Jin Hosp, Natl Res Ctr Translat Med, State Key Lab Med Genom,Sch Med,Shanghai Inst Hem, Shanghai 200025, Peoples R China

[12] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[13] Univ Macau, Fac Hlth Sci, Ctr Precis Med Res & Training, Macau 999087, Peoples R China

来源：

BIOINFORMATICS | 2022年 / 38卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1093/bioinformatics/btab561

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

UCSC Xena platform provides huge amounts of processed cancer omics data from large cancer research projects (e.g. TCGA, CCLE and PCAWG) or individual research groups and enables unprecedented research opportunities. However, a graphical user interface-based tool for interactively analyzing UCSC Xena data and generating elegant plots is still lacking, especially for cancer researchers and clinicians with limited programming experience. Here, we present UCSCXenaShiny, an R Shiny package for quickly searching, downloading, exploring, analyzing and visualizing data from UCSC Xena data hubs. This tool could effectively promote the practical use of public data, and can serve as an important complement to the current Xena genomics explorer.

引用

页码：527 / 529

页数：3

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