Exiguaquinol:: A novel pentacyclic hydroquinone from Neopetrosia exigua that inhibits Helicobacter pylori murl

被引：45

作者：

Leone, Priscila de Almeida ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Towerzey, Leanne ^{[1
]}

King, Gordon ^{[1
]}

McArdle, Bernadette M. ^{[1
]}

Kern, Gunther ^{[2
]}

Fisher, Stewart ^{[2
]}

Hooper, John N. A. ^{[3
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] AstraZeneca R&D Boston, Infect Discovery, Waltham, MA 02451 USA

[3] Queensland Museum, Brisbane, Qld 4101, Australia

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800898z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (Murl) with an IC(50) of 4.4 mu M. Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori Murl. Its protein-ligand modeling is also discussed.

引用

页码：2585 / 2588

页数：4

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