Successful Treatment of Severe Adenoviral ARDS Using Cidofovir in a Case with Cerebral Palsy

被引：0

作者：

Gun, Emrah ^{[1
]}

Kendirli, Tanil ^{[1
]}

Havan, Merve ^{[1
]}

Ozcan, Serhan ^{[1
]}

Balsak, Serdar ^{[1
]}

Botan, Edin ^{[1
]}

Konca, Hatice Kubra ^{[2
]}

Ince, Erdal ^{[2
]}

机构：

[1] Ankara Univ, Cocuk Yogun Bakim Bilim Dali, Tip Fak, Ankara, Turkey

[2] Ankara Univ, Cocuk Enfeksiyonlari Hastaliklari Bilim Dali, Tip Fak, Ankara, Turkey

来源：

JOURNAL OF PEDIATRIC EMERGENCY AND INTENSIVE CARE MEDICINE | 2021年 / 8卷 / 01期

关键词：

Adenovirus; cidofovir; child; pediatric respiratory distress syndrome; pneumonia; INFECTIONS;

D O I：

10.4274/cayd.galenos.2019.97759

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Adenovirus is a non-enveloped, double-stranded DNA virus that can cause infections in the upper and lower respiratory tract, conjunctiva, and gastrointestinal tract. Adenovirus infections are usually mild but may cause mortality and morbidity, especially in immunocompromised patients. Cidofovir may be used to treat adenovirus. Cidofovir is an antiviral with a virostatic effect, especially effective for adenovirus and herpes virus. In this case report, we present a 15-year-old patient with adenovirus-induced severe acute respiratory distress syndrome, who was referred to us for renal failure and successfully treated with cidofovir.

引用

页码：50 / 53

页数：4

共 11 条

[1]

Alcamo AM, 2015, J PEDIAT HEMATOL ONC, V37, pE178, DOI 10.1097/MPH.0000000000000224

[2] Pharmacokinetics and Safety of Intravenous Cidofovir for Life-Threatening Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients [J].

Brown, Amy E. Caruso ;

Cohen, Mindy N. ;

Tong, Suhong ;

Braverman, Rebecca S. ;

Rooney, James F. ;

Giller, Roger ;

Levin, Myron J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (07) :3718-3725

[3] Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children [J].

Gavin, PJ ;

Katz, BZ .

PEDIATRICS, 2002, 110 (01) :e9

[4] Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation [J].

Hoffman, JA ;

Shah, AJ ;

Ross, LA ;

Kapoor, N .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2001, 7 (07) :388-394

[5] Case presentation: persistent adenovirus B3 infections associated with bronchiolitis obliterans treated with cidofovir in a child with mosaic tetrasomy 9p [J].

Ions, Rhiannon ;

Narayanan, Manjith ;

Browning, Michael ;

Gaillard, Erol A. ;

Stiefel, Gary ;

Tang, Julian W. .

BMC INFECTIOUS DISEASES, 2018, 18

[6] Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia [J].

Kim, Se Jin ;

Kim, Kang ;

Park, Sung Bum ;

Hong, Duck Jin ;

Jhun, Byung Woo .

PLOS ONE, 2015, 10 (04)

[7] Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia [J].

Lim, Li Min ;

Woo, Yen Yen ;

de Bruyne, Jessie Anne ;

Nathan, Anna Marie ;

Kee, Sze Ying ;

Chan, Yoke Fun ;

Chiam, Chun Wei ;

Eg, Kah Peng ;

Thavagnanam, Surendran ;

Sam, I-Ching .

PLOS ONE, 2018, 13 (10)

[8] Adenovirus-related epidemic keratoconjunctivitis outbreak at a hospital-affiliated ophthalmology clinic [J].

Muller, Matthew P. ;

Siddiqui, Naureen ;

Ivancic, Rose ;

Wong, David .

AMERICAN JOURNAL OF INFECTION CONTROL, 2018, 46 (05) :581-583

[9] Renal Toxicity in Pediatric Patients Receiving Cidofovir for the Treatment of Adenovirus Infection [J].

Vora, Surabhi B. ;

Brothers, Adam W. ;

Englund, Janet A. .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2017, 6 (04) :399-402

[10] Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia [J].

Xie, Leyun ;

Zhang, Bing ;

Zhou, Jieying ;

Huang, Han ;

Zeng, Saizhen ;

Liu, Qin ;

Xie, Zhiping ;

Gao, Hanchun ;

Duan, Zhaojun ;

Zhong, Lili .

VIROLOGY JOURNAL, 2018, 15

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