A novel liposome-encapsulated hemoglobin/silica nanoparticle as an oxygen carrier

被引：38

作者：

Liu, Mingxian ^{[1
]}

Gan, Lihua ^{[1
]}

Chen, Liuhua ^{[1
]}

Zhu, Dazhang ^{[1
]}

Xu, Zijie ^{[1
]}

Hao, Zhixian ^{[1
]}

Chen, Longwu ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 427卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LEHSN; Liposome; Hemoglobin; Silica nanoparticle; Emulsion; Oxygen carrier; BLOOD SUBSTITUTES;

D O I：

10.1016/j.ijpharm.2012.02.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel liposome-encapsulated hemoglobin/silica nanoparticle (LEHSN) was fabricated by a water-in-oil-in-water (W/O/W) double emulsion approach. Bovine hemoglobin (Hb) was first adsorbed onto the surfaces of silica nanoparticles (SNs), and then the complex of Hb/SNs was encapsulated by liposome to form LEHSN which has a core-shell supramolecular structure. On the one hand, liposomes built a cell membrane-like environment for the controlled release of Hb. On the other hand, SNs which act as rigid core provide a supported framework for lecithin membrane, and enhance the stability of liposomes. In comparison with liposome-encapsulated Hb (LEH), LEHSN shows substantially enhanced stability and improved release property of Hb in vitro. This study highlights the potential of the novel LEHSN as an oxygen carrier for pharmaceutical applications. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：354 / 357

页数：4

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