Nanoparticles in Clinical Translation for Cancer Therapy

被引：174
作者：
Mundekkad, Deepa [1 ]
Cho, William C. [2 ]
机构：
[1] Vellore Inst Technol, Ctr NanoBioTechnol CNBT, Vellore 632014, Tamil Nadu, India
[2] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期
关键词：
nanoparticles; cancer therapy; nanodrugs; nanochemotherapy; nanomedicine; IN-VITRO EVALUATION; GOLD NANOPARTICLES; DRUG-DELIVERY; REACTIVE OXYGEN; CELLULAR INTERNALIZATION; POLYMERIC MICELLES; RADIATION-THERAPY; OXIDATIVE STRESS; PHASE-II; MELANOMA;
D O I：
10.3390/ijms23031685
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. The new therapeutic modalities accomplished through the properties of nanomaterials have extended their scope in cancer therapy beyond conventional drug delivery. Nanoparticles can be channeled in cancer therapy to encapsulate active pharmaceutical ingredients and deliver them to the tumor site in a more efficient manner. This review enumerates various types of nanoparticles that have entered clinical trials for cancer treatment. The obstacles in the journey of nanodrug from clinic to market are reviewed. Furthermore, the latest developments in using nanoparticles in cancer therapy are also highlighted.
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页数：29
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