Purification of Nano-Porous Silicon for Biomedical Applications

被引：16

作者：

Koynov, Svetoslav ^{[1
]}

Pereira, Rui N. ^{[1
]}

Crnolatac, Ivo ^{[4
]}

Kovalev, Dmitry ^{[2
]}

Huygens, Ann ^{[4
]}

Chirvony, Vladimir ^{[3
]}

Stutzmann, Martin ^{[1
]}

de Witte, Peter ^{[4
]}

机构：

[1] Tech Univ Munich, Walter Schottky Inst, D-85748 Garching, Germany

[2] Univ Bath, Dept Phys, Bath BA2 7AY, Avon, England

[3] Univ Valencia, Inst Ciencia Mat, Valencia 46071, Spain

[4] Katholieke Univ Leuven, B-3000 Louvain, Belgium

来源：

ADVANCED ENGINEERING MATERIALS | 2011年 / 13卷 / 06期

关键词：

VISIBLE LUMINESCENCE; OXYGEN MOLECULES; SINGLET OXYGEN; NANOCRYSTALS; FABRICATION; PHOTOSENSITIZERS; WAFERS;

D O I：

10.1002/adem.201080091

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Recently, various bio-medical applications of nanoporous silicon (np-Si) have been suggested. This work investigates the biocompatibility of np-Si particles taking into account hazardous residua confined in the pores after preparation. The emphasis is on the potential application of such particles as oxygen photosensitizer for photodynamic therapy of cancer, which requires both negligible toxicity of np-Si particles in darkness and a high photo-cyto-toxic effect due to generation of singlet oxygen under illumination. Considerable amounts of water soluble toxic impurities are found to be present in the nanoporous shell of micrometer-sized np-Si particles immediately after their preparation by chemical etching of bulk silicon powder. The effects of several ordinary cleaning treatments are investigated by using thermal effusion mass-spectroscopy and FTIR spectroscopy. A particular purification procedure is developed, capable to reduce the concentration of residual impurities to levels acceptable for bio-medical applications while preserving the required photo-activity of the np-Si particles.

引用

页码：B225 / B233

页数：9

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