Synthesis of 2H-1,4-Benzoxazin-3(4H)-ones via Smiles Rearrangement

被引：0

作者：

Zhou, Jia-Zhou ^{[1
]}

Li, Zhu-Bo ^{[1
]}

Yang, Hao ^{[2
]}

He, Xiao-Yan ^{[1
]}

Wang, Li-Ying ^{[1
]}

Tian, Xiao ^{[1
]}

Lv, Ting Ting ^{[1
]}

Zuo, Hua ^{[1
]}

机构：

[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

[2] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing 400715, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Smiles rearrangement; 2H-1,4-Benzoxazin-3(4H)-one; Synthesis; Hindered molecule; DERIVATIVES; DESIGN; INHIBITORS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthetic route for novel 2H-1,4-benzoxazin-3(4H)-ones via smiles rearrangement is developed. Reaction of primary amine and chloroacetyl chloride gave 2-chloroacetamide, which reacted with 2-chlorophenol, followed by Smiles rearrangement to obtain a series of new 2H-1,4-benzoxazin-3(4H)-ones (yield 45-90 %).

引用

页码：2947 / 2950

页数：4

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