Synthesis of 2H-1,4-Benzoxazin-3(4H)-ones via Smiles Rearrangement

被引：0
作者：
Zhou, Jia-Zhou [1 ]
Li, Zhu-Bo [1 ]
Yang, Hao [2 ]
He, Xiao-Yan [1 ]
Wang, Li-Ying [1 ]
Tian, Xiao [1 ]
Lv, Ting Ting [1 ]
Zuo, Hua [1 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China
[2] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing 400715, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Smiles rearrangement; 2H-1,4-Benzoxazin-3(4H)-one; Synthesis; Hindered molecule; DERIVATIVES; DESIGN; INHIBITORS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient synthetic route for novel 2H-1,4-benzoxazin-3(4H)-ones via smiles rearrangement is developed. Reaction of primary amine and chloroacetyl chloride gave 2-chloroacetamide, which reacted with 2-chlorophenol, followed by Smiles rearrangement to obtain a series of new 2H-1,4-benzoxazin-3(4H)-ones (yield 45-90 %).
引用
收藏
页码：2947 / 2950
页数：4
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