Spoils of war: iron at the crux of clinical and ecological fitness of Pseudomonas aeruginosa

被引：18

作者：

Nguyen, Angela T. ^{[1
]}

Oglesby-Sherrouse, Amanda G. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

BIOMETALS | 2015年 / 28卷 / 03期

关键词：

Pseudomonas aeruginosa; Iron; Heme; PQS; GRAM-NEGATIVE BACTERIA; HEME OXYGENASE; FERROUS IRON; LUNG INFECTIONS; UPTAKE SYSTEMS; SIDEROPHORE; PYOVERDINE; VIRULENCE; TRANSPORT; GENE;

D O I：

10.1007/s10534-015-9848-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudomonas aeruginosa is a versatile environmental microorganism that also causes life-threatening opportunistic infections. At the root of this bacterium's ability to survive in such diverse environments is its large suite of iron acquisition systems. More recently, studies have highlighted the ability of P. aeruginosa to compete with other organisms for this essential metallonutrient. This minireview provides an overview of the iron acquisition systems used by P. aeruginosa, with an emphasis on how these systems contribute to fitness in polymicrobial environments. We also provide an evolutionary perspective of how these systems were selected for in the native habitats of the Pseudomonads, while also highlighting factors that are unique to P. aeruginosa.

引用

页码：433 / 443

页数：11

共 98 条

[1] Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity [J].

Adler, Conrado ;

Corbalan, Natalia S. ;

Seyedsayamdost, Mohammad R. ;

Pomares, Maria Fernanda ;

de Cristobal, Ricardo E. ;

Clardy, Jon ;

Kolter, Roberto ;

Vincent, Paula A. .

PLOS ONE, 2012, 7 (10)

[2] BACTERIAL IRON TRANSPORT - COORDINATION PROPERTIES OF PYOVERDIN PAA, A PEPTIDIC SIDEROPHORE OF PSEUDOMONAS-AERUGINOSA [J].

ALBRECHTGARY, AM ;

BLANC, S ;

ROCHEL, N ;

OCAKTAN, AZ ;

ABDALLAH, MA .

INORGANIC CHEMISTRY, 1994, 33 (26) :6391-6402

[3] Bacterial iron homeostasis [J].

Andrews, SC ;

Robinson, AK ;

Rodríguez-Quiñones, F .

FEMS MICROBIOLOGY REVIEWS, 2003, 27 (2-3) :215-237

[4] Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens [J].

Anzaldi, Laura L. ;

Skaar, Eric P. .

INFECTION AND IMMUNITY, 2010, 78 (12) :4977-4989

[5] Chemical aspects of siderophore mediated iron transport [J].

Boukhalfa, H ;

Crumbliss, AL .

BIOMETALS, 2002, 15 (04) :325-339

[6] Pyochelin, a siderophore of Pseudomonas aeruginosa: Physicochemical characterization of the iron(III), copper(II) and zinc(II) complexes [J].

Brandel, Jeremy ;

Humbert, Nicolas ;

Elhabiri, Mourad ;

Schalk, Isabelle J. ;

Mislin, Gaetan L. A. ;

Albrecht-Gary, Anne-Marie .

DALTON TRANSACTIONS, 2012, 41 (09) :2820-2834

[7] New insights into the metal specificity of the Pseudomonas aeruginosa pyoverdine-iron uptake pathway [J].

Braud, Armelle ;

Hoegy, Francoise ;

Jezequel, Karine ;

Lebeau, Thierry ;

Schalk, Isabelle J. .

ENVIRONMENTAL MICROBIOLOGY, 2009, 11 (05) :1079-1091

[8] The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity [J].

Bredenbruch, Florian ;

Geffers, Robert ;

Nimtz, Manfred ;

Buer, Jan ;

Haeussler, Susanne .

ENVIRONMENTAL MICROBIOLOGY, 2006, 8 (08) :1318-1329

[9] Heme transport contributes to in vivo fitness of Bordetella pertussis during primary infection in mice [J].

Brickman, TJ ;

Vanderpool, CK ;

Armstrong, SK .

INFECTION AND IMMUNITY, 2006, 74 (03) :1741-1744

[10] National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004 [J].

Cardo, D ;

Horan, T ;

Andrus, M ;

Dembinski, M ;

Edwards, J ;

Peavy, G ;

Tolson, J ;

Wagner, D .

AMERICAN JOURNAL OF INFECTION CONTROL, 2004, 32 (08) :470-485

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