Expanding the Scope of the Direct Regiospecific Asymmetric Aldol Reaction to Enones and Dienones Catalyzed by a BINOL-Derived Bronsted Acid

被引：12

作者：

Das, Joydeb ^{[1
]}

Le Cavelier, Fabien ^{[1
]}

Rouden, Jacques ^{[1
]}

Blanchet, Jerome ^{[1
]}

机构：

[1] Univ Caen, Lab Chim Mol & Thioorgan, ENSICAEN, INC3M FR 3038,UMR CNRS 6507, F-14050 Caen, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 33期

关键词：

Organocatalysis; Aldol reactions; Bronsted acids; Enones; Asymmetric synthesis; PHOSPHORIC-ACIDS; ALDEHYDES; KETONES; YNONES;

D O I：

10.1002/ejoc.201101282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral phosphoric acid (R)-1a has been shown to be an efficient Bronsted acid catalyst for the useful asymmetric synthesis of various acyclic and endo- and exocyclic beta-hydroxyenones through a regiospecific aldol reaction between alpha,beta-unsaturated ketones and ethyl glyoxalate. Moreover, two unprecedented examples involving sensitive dienones are reported.

引用

页码：6628 / 6631

页数：4

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