Tau-positron emission tomography correlates with neuropathology findings

被引：120

作者：

Lowe, Val J. ^{[1
]}

Lundt, Emily S. ^{[2
]}

Albertson, Sabrina M. ^{[2
]}

Min, Hoon-Ki ^{[1
]}

Fang, Ping ^{[1
]}

Przybelski, Scott A. ^{[2
]}

Senjem, Matthew L. ^{[3
]}

Schwarz, Christopher G. ^{[1
]}

Kantarci, Kejal ^{[1
]}

Boeve, Bradley ^{[4
]}

Jones, David T. ^{[4
]}

Reichard, R. Ross ^{[5
]}

Tranovich, Jessica F. ^{[6
]}

Al-Shaikh, Fadi S. Hanna ^{[6
]}

Knopman, David S. ^{[4
]}

Jack, Clifford R., Jr. ^{[1
]}

Dickson, Dennis W. ^{[6
,7
]}

Petersen, Ronald C. ^{[4
]}

Murray, Melissa E. ^{[6
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Informat Technol, Rochester, MN USA

[4] Mayo Clin, Dept Neurol, Rochester, MN USA

[5] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[6] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[7] Mayo Clin, Dept Lab Med & Pathol, Jacksonville, FL 32224 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 03期

关键词：

Alzheimer's disease; Autopsy; Braak tangle stage; flortaucipir; PET; Tau; ALZHEIMERS ASSOCIATION GUIDELINES; NEUROFIBRILLARY TANGLES; NATIONAL INSTITUTE; DISEASE CERAD; LEWY BODIES; DEMENTIA; PATHOLOGY; CONSORTIUM; ESTABLISH; CRITERIA;

D O I：

10.1016/j.jalz.2019.09.079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Comparison of tau (flortaucipir) positron emission tomography (FTPPET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Methods: Autopsies were performed on 26 participantswho had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTPPET signal. Results: Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P <= .02). Discussion: Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.

引用

页码：561 / 571

页数：11

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