Tau-positron emission tomography correlates with neuropathology findings

被引：129

作者：

Lowe, Val J. ^{[1
]}

Lundt, Emily S. ^{[2
]}

Albertson, Sabrina M. ^{[2
]}

Min, Hoon-Ki ^{[1
]}

Fang, Ping ^{[1
]}

Przybelski, Scott A. ^{[2
]}

Senjem, Matthew L. ^{[3
]}

Schwarz, Christopher G. ^{[1
]}

Kantarci, Kejal ^{[1
]}

Boeve, Bradley ^{[4
]}

Jones, David T. ^{[4
]}

Reichard, R. Ross ^{[5
]}

Tranovich, Jessica F. ^{[6
]}

Al-Shaikh, Fadi S. Hanna ^{[6
]}

Knopman, David S. ^{[4
]}

Jack, Clifford R., Jr. ^{[1
]}

Dickson, Dennis W. ^{[6
,7
]}

Petersen, Ronald C. ^{[4
]}

Murray, Melissa E. ^{[6
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Informat Technol, Rochester, MN USA

[4] Mayo Clin, Dept Neurol, Rochester, MN USA

[5] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[6] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[7] Mayo Clin, Dept Lab Med & Pathol, Jacksonville, FL 32224 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 03期

关键词：

Alzheimer's disease; Autopsy; Braak tangle stage; flortaucipir; PET; Tau; ALZHEIMERS ASSOCIATION GUIDELINES; NEUROFIBRILLARY TANGLES; NATIONAL INSTITUTE; DISEASE CERAD; LEWY BODIES; DEMENTIA; PATHOLOGY; CONSORTIUM; ESTABLISH; CRITERIA;

D O I：

10.1016/j.jalz.2019.09.079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Comparison of tau (flortaucipir) positron emission tomography (FTPPET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Methods: Autopsies were performed on 26 participantswho had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTPPET signal. Results: Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P <= .02). Discussion: Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.

引用

页码：561 / 571

页数：11

共 43 条

[1] Globular glial tauopathies (GGT): consensus recommendations [J].

Ahmed, Zeshan ;

Bigio, Eileen H. ;

Budka, Herbert ;

Dickson, Dennis W. ;

Ferrer, Isidro ;

Ghetti, Bernardino ;

Giaccone, Giorgio ;

Hatanpaa, Kimmo J. ;

Holton, Janice L. ;

Josephs, Keith A. ;

Powers, James ;

Spina, Salvatore ;

Takahashi, Hitoshi ;

White, Charles L., III ;

Revesz, Tamas ;

Kovacs, Gabor G. .

ACTA NEUROPATHOLOGICA, 2013, 126 (04) :537-544

[2] Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function [J].

Bennett, DA ;

Schneider, JA ;

Wilson, RS ;

Bienias, JL ;

Arnold, SE .

ARCHIVES OF NEUROLOGY, 2004, 61 (03) :378-384

[3] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[4] Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].

Braak, Heiko ;

Alafuzoff, Irina ;

Arzberger, Thomas ;

Kretzschmar, Hans ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404

[5] Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807 [J].

Chien, David T. ;

Bahri, Shadfar ;

Szardenings, A. Katrin ;

Walsh, Joseph C. ;

Mu, Fanrong ;

Su, Min-Ying ;

Shankle, William R. ;

Elizarov, Arkadij ;

Kolb, Hartmuth C. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 34 (02) :457-468

[6] Primary age-related tauopathy (PART): a common pathology associated with human aging [J].

Crary, John F. ;

Trojanowski, John Q. ;

Schneider, Julie A. ;

Abisambra, Jose F. ;

Abner, Erin L. ;

Alafuzoff, Irina ;

Arnold, Steven E. ;

Attems, Johannes ;

Beach, Thomas G. ;

Bigio, Eileen H. ;

Cairns, Nigel J. ;

Dickson, Dennis W. ;

Gearing, Marla ;

Grinberg, Lea T. ;

Hof, Patrick R. ;

Hyman, Bradley T. ;

Jellinger, Kurt ;

Jicha, Gregory A. ;

Kovacs, Gabor G. ;

Knopman, David S. ;

Kofler, Julia ;

Kukull, Walter A. ;

Mackenzie, Ian R. ;

Masliah, Eliezer ;

McKee, Ann ;

Montine, Thomas J. ;

Murray, Melissa E. ;

Neltner, Janna H. ;

Santa-Maria, Ismael ;

Seeley, William W. ;

Serrano-Pozo, Alberto ;

Shelanski, Michael L. ;

Stein, Thor ;

Takao, Masaki ;

Thal, Dietmar R. ;

Toledo, Jonathan B. ;

Troncoso, Juan C. ;

Vonsattel, Jean Paul ;

White, Charles L., III ;

Wisniewski, Thomas ;

Woltjer, Randall L. ;

Yamada, Masahito ;

Nelson, Peter T. .

ACTA NEUROPATHOLOGICA, 2014, 128 (06) :755-766

[7] In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease [J].

Day, Gregory S. ;

Gordon, Brian A. ;

Perrin, Richard J. ;

Cairns, Nigel J. ;

Beaumont, Helen ;

Schwetye, Katherine ;

Ferguson, Cole ;

Sinha, Namita ;

Bucelli, Robert ;

Musiek, Erik S. ;

Ghoshal, Nupur ;

Ponisio, Maria R. ;

Vincent, Benjamin ;

Mishra, Shruti ;

Jackson, Kelley ;

Morris, John C. ;

Benzinger, Tammie L. S. ;

Ances, Beau M. .

NEUROLOGY, 2018, 90 (10) :E896-E906

[8] Office of rare diseases neuropathologic criteria for corticobasal degeneration [J].

Dickson, DW ;

Bergeron, C ;

Chin, SS ;

Duyckaerts, C ;

Horoupian, D ;

Ikeda, K ;

Jellinger, K ;

Lantos, PL ;

Lippa, CF ;

Mirra, SS ;

Tabaton, M ;

Vonsattel, JP ;

Wakabayashi, K ;

Litvan, I .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (11) :935-946

[9] Modeling the relation between neurofibrillary tangles and intellectual status [J].

Duyckaerts, C ;

Bennecib, M ;

Grignon, Y ;

Uchihara, T ;

He, Y ;

Piette, F ;

Hauw, JJ .

NEUROBIOLOGY OF AGING, 1997, 18 (03) :267-273

[10] High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer's Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection [J].

Fawaz, Maria V. ;

Brooks, Allen F. ;

Rodnick, Melissa E. ;

Carpenter, Garrett M. ;

Shao, Xia ;

Desmond, Timothy J. ;

Sherman, Phillip ;

Quesada, Carole A. ;

Hockley, Brian G. ;

Kilbourn, Michael R. ;

Albin, Roger L. ;

Frey, Kirk A. ;

Scott, Peter J. H. .

ACS CHEMICAL NEUROSCIENCE, 2014, 5 (08) :718-730

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