Effect of carvedilol against myocardial injury due to ischemia-reperfusion of the brain in rats

被引：8

作者：

Harima, Meilei ^{[1
]}

Arumugam, Somasundaram ^{[1
]}

Wen, Juan ^{[1
]}

Pitchaimani, Vigneshwaran ^{[1
]}

Karuppagounder, Vengadeshprabhu ^{[1
]}

Afrin, Mst. Rejina ^{[1
]}

Sreedhar, Remya ^{[1
]}

Miyashita, Shizuka ^{[1
]}

Nomoto, Mayumi ^{[1
]}

Ueno, Kazuyuki ^{[2
]}

Nakamura, Masahiko ^{[3
]}

Watanabe, Kenichi ^{[1
]}

机构：

[1] Niigata Univ Pharm & Appl Life Sci, Dept Clin Pharmacol, Akiha Ku, Niigata 9568603, Japan

[2] Niigata Univ Pharm & Appl Life Sci, Dept Pharmaceut Sci, Akiha Ku, Niigata 9568603, Japan

[3] Yamanashi Prefectural Cent Hosp, Dept Cardiol, Kofu, Yamanashi, Japan

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2015年 / 98卷 / 03期

关键词：

Carvedilol; Cardiac injury; Ischemia-reperfusion; Brain; Apoptosis; OXIDATIVE STRESS; INTRACRANIAL-PRESSURE; APOPTOSIS; PROTECTS; ANTIOXIDANT; INVOLVEMENT; DYSFUNCTION; INFARCTION; DAMAGE;

D O I：

10.1016/j.yexmp.2015.04.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We have previously reported the mechanism behind the myocardial injury and the activation of autonomic nervous system during the ischemia-reperfusion (IR) of the rat brain. This study was planned to investigate the effect of carvedilol, a (beta-blacker, in improving the myocardial injury caused by IR of the rat brain. We have used a whole cerebral IR model in rats by clamping both the right and left common carotid arteries. Rats were divided into five groups; Sham surgery group (Group-Sham), carvedilol treatment before ischemia group (Group-Is + C), vehicle control group (Group-Is + V), carvedilol treatment before reperfusion group (Group-Re + C) and the vehicle control group (Group-Re + V). We have measured the blood pressure and heart rate via a catheter, myocardial tissue (beta 1-adrenaline receptor (beta 1-AR) levels, phosphor-p38 mitogen-activated protein kinase (p-p38 MAPK) signaling factor, malondialdehyde (MDA), and apoptosis (TUNEL assay and expression of caspase-7 protein). The results indicated that the increased expressions of beta 1-AR, p-p38 MAPK, caspase-7, apoptotic cells and MDA level in the myocardial tissue due to brain ischemia-reperfusion were significantly reduced by carvedilol treatment. From these observations we can suggest that, with the advantage of its antioxidant and beta blocking action, carvedilol had played the improvement of myocardial injury in ischemia-reperfusion of the brain. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：558 / 562

页数：5

共 22 条

[1] PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia [J].

Armstead, William M. ;

Riley, John ;

Kiessling, J. Willis ;

Cines, Douglas B. ;

Higazi, Abd Al-Roof .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 299 (01) :H76-H80

[2]

Arozal W., 2011, ISRN PHARM

[3] Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy [J].

Arumugam, Somasundaram ;

Thandavarayan, Rajarajan A. ;

Veeraveedu, Punniyakoti T. ;

Nakamura, Takashi ;

Arozal, Wawaimuli ;

Sari, Flori R. ;

Giridharan, Vijayasree V. ;

Soetikno, Vivian ;

Palaniyandi, Suresh S. ;

Harima, Meilei ;

Suzuki, Kenji ;

Nagata, Masaki ;

Kodama, Makoto ;

Watanabe, Kenichi .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (09) :2176-2185

[4] Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis [J].

Arumugam, Somasundaram ;

Thandavarayan, Rajarajan A. ;

Palaniyandi, Suresh S. ;

Giridharan, Vijayasree V. ;

Arozal, Wawaimuli ;

Sari, Flori R. ;

Soetikno, Vivian ;

Harima, Meilei ;

Suzuki, Kenji ;

Kodama, Makoto ;

Watanabe, Kenichi .

TOXICOLOGY, 2012, 291 (1-3) :139-145

[5] Opposing effects of β1- and β2-adrenergic receptors on cardiac myocyte apoptosis -: Role of a pertussis toxin-sensitive G proteins [J].

Communal, C ;

Singh, K ;

Sawyer, DB ;

Colucci, WS .

CIRCULATION, 1999, 100 (22) :2210-2212

[6]

DAVIS AM, 1993, TEX HEART I J, V20, P158

[7] Beta-Blockers Reduced the Risk of Mortality and Exacerbation in Patients with COPD: A Meta-Analysis of Observational Studies [J].

Du, Qingxia ;

Sun, Yongchang ;

Ding, Ning ;

Lu, Lijin ;

Chen, Ying .

PLOS ONE, 2014, 9 (11)

[8] Carvedilol improves ethanol-induced liver injury via modifying the interaction between oxidative stress and sympathetic hyperactivity in rats [J].

Hakucho, Ayako ;

Liu, Jinyao ;

Liu, Xu ;

Fujimiya, Tatsuya .

HEPATOLOGY RESEARCH, 2014, 44 (05) :560-570

[9] Carvedilol Enhances Mesenchymal Stem Cell Therapy for Myocardial Infarction via Inhibition of Caspase-3 Expression [J].

Hassan, Fatemat ;

Meduru, Sarath ;

Taguchi, Kazuaki ;

Kuppusamy, M. Lakshmi ;

Mostafa, Mahmoud ;

Kuppusamy, Periannan ;

Khan, Mahmood .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 343 (01) :62-71

[10] In vitro antioxidant potentials of traditional Chinese medicine, Shengmai San and their relation to in vivo protective effect on cerebral oxidative damage in rats [J].

Ichikawa, H ;

Konishi, T .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2002, 25 (07) :898-903

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