Novel Biomarkers for Prostate Cancer Detection and Prognosis

被引：21

作者：

Filella, Xavier ^{[1
]}

Foj, Laura ^{[1
]}

机构：

[1] Hosp Clin Barcelona, IDIBAPS, Dept Biochem & Mol Genet CDB, Barcelona, Catalonia, Spain

来源：

CELL & MOLECULAR BIOLOGY OF PROSTATE CANCER: UPDATES, INSIGHTS AND NEW FRONTIERS | 2018年 / 1095卷

关键词：

Prostate cancer detection; Biomarker; PSA; Prostate health index; 4Kscore; PCA3; score; miRNAs; Exosomal biomarkers; PROPROSTATE-SPECIFIC ANTIGEN; INDEX-BASED NOMOGRAM; TOTAL PSA RANGE; HEALTH INDEX; 4-KALLIKREIN PANEL; CIRCULATING MICRORNAS; ACTIVE SURVEILLANCE; RISK STRATIFICATION; CLINICAL UTILITY; PRECURSOR FORM;

D O I：

10.1007/978-3-319-95693-0_2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostate cancer (PCa) remains as one of the most controversial issues in health care because of the dilemmas related to screening using Prostate Specific Antigen (PSA). A high number of false positive biopsies and an elevated rate of overdiagnosis are the main problems associated with PSA. New PCa biomarkers have been recently proposed to increase the predictive value of PSA. The published results showed that PCA3 score, Prostate Health Index and 4Kscore can reduce the number of unnecessary biopsies, outperforming better than PSA and the percentage of free PSA. Furthermore, 4Kscore provides with high accuracy an individual risk for high-grade PCa. High values of PHI are also associated with tumor aggressiveness. In contrast, the relationship of PCA3 score with aggressiveness remains controversial, with studies showing opposite conclusions. Finally, the development of molecular biology has opened the study of genes, among them TMPRSS2:ERG fusion gene and miRNAs, in PCa detection and prognosis.

引用

页码：15 / 39

页数：25

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