Metabolic Control of Longevity

被引：552

作者：

Lopez-Otin, Carlos ^{[1
]}

Galluzzi, Lorenzo ^{[2
,3
,4
,5
,6
,7
]}

Freije, Jose M. P. ^{[1
]}

Madeo, Frank ^{[8
,9
]}

Kroemer, Guido ^{[3
,4
,5
,6
,10
,11
,12
]}

机构：

[1] Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, E-33006 Oviedo, Spain

[2] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[3] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, F-75006 Paris, France

[4] Inst Natl Sante & Rech Med, U1138, F-75006 Paris, France

[5] Univ Paris Descartes Paris V, Sorbonne Paris Cite, F-75006 Paris, France

[6] Univ Pierre & Marie Curie Paris VI, F-75006 Paris, France

[7] Gustave Roussy Canc Campus, F-94805 Villejuif, France

[8] Graz Univ, NAWI Graz, Inst Mol Biosci, A-8010 Graz, Austria

[9] BioTechMed Graz, A-8010 Graz, Austria

[10] Hop Europeen Georges Pompidou, AP HP, Pole Biol, F-75015 Paris, France

[11] Karolinska Inst, Karolinska Univ Hosp, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden

[12] Gustave Roussy Canc Campus, F-94805 Villejuif, France

来源：

CELL | 2016年 / 166卷 / 04期

基金：

欧洲研究理事会;

关键词：

EXTENDS LIFE-SPAN; ADIPOSE-TISSUE; MOUSE MODEL; DNA-DAMAGE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; CIRCADIAN CLOCK; OBESE MICE; PHARMACOLOGICAL INHIBITION; NORDIHYDROGUAIARETIC ACID;

D O I：

10.1016/j.cell.2016.07.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock'' that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the "westernized'' lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.

引用

页码：802 / 821

页数：20

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