Nasopharyngeal Carcinoma: Clinical Achievements and Considerations Among Treatment Options

被引:30
作者
Liu, Zheran [1 ]
Chen, Ye [2 ]
Su, Yonglin [1 ,3 ]
Hu, Xiaolin [4 ]
Peng, Xingchen [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Biotherapy, Ctr Canc, Chengdu, Peoples R China
[2] Sichuan Univ, Dept Med Oncol, Ctr Canc, State Key Lab Biotherapy,West China Hosp,West Chi, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Rehabil, Ctr Canc, Chengdu, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Nursing, Chengdu, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金
中国国家自然科学基金;
关键词
nasopharyngeal carcinoma; intensity-modulated radiotherapy; chemotherapy; targeted therapy; immunotherapy; INTENSITY-MODULATED RADIOTHERAPY; RANDOMIZED PHASE-II; CONCURRENT CISPLATIN-RADIOTHERAPY; LONG-TERM SURVIVAL; INDUCTION CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; STAGE-II; CONFORMAL RADIOTHERAPY; DISTANT METASTASIS; ANTITUMOR-ACTIVITY;
D O I
10.3389/fonc.2021.635737
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nasopharyngeal carcinoma (NPC) is a severe malignancy arising from the nasopharyngeal epithelium and is southern China's third most common cancer. With the advancement of treatment methods, early-stage NPC patients usually have a better prognosis and more prolonged survival period than those with other malignant tumors. Most treatment failures are due to distant metastasis or a locally advanced stage of NPC in the initial diagnosis. In addition, approximately 10% of patients develop local recurrence, and 10%-20% of patients experience distant metastasis after treatment. These patients have a poor prognosis, with a median survival of only approximately 10-15 months. In the rapid development of treatment options, the efficacy and safety of some treatments have been validated and approved for first-line treatment, while those of other treatments remain unclear. The present study aims to provide a comprehensive overview of recent advances in NPC treatment and explain the various therapeutic possibilities in treating locally advanced, recurrent, and metastatic NPC patients.
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页数:11
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