Human Ageing Genomic Resources: new and updated databases

被引：490

作者：

Tacutu, Robi ^{[1
,2
]}

Thornton, Daniel ^{[1
]}

Johnson, Emily ^{[1
]}

Budovsky, Arie ^{[3
,4
]}

Barardo, Diogo ^{[5
,6
]}

Craig, Thomas ^{[1
]}

Diana, Eugene ^{[1
]}

Lehmann, Gilad ^{[3
]}

Toren, Dmitri ^{[3
]}

Wang, Jingwei ^{[1
]}

Fraifeld, Vadim E. ^{[3
]}

de Magalhaes, Joao P. ^{[1
]}

机构：

[1] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, Liverpool L7 8TX, Merseyside, England

[2] Romanian Acad, Inst Biochem, Computat Biol Aging Grp, Bucharest 060031, Romania

[3] Ben Gurion Univ Negev, Ctr Multidisciplinary Res Aging, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel

[4] Judea Reg Res & Dev Ctr, IL-90404 Carmel, Israel

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

[6] Yale NUS Coll, Sci Div, Singapore 138527, Singapore

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

英国惠康基金;

关键词：

CELLULAR SENESCENCE; HUMAN LONGEVITY; BIOLOGY; RESTRICTION; SYSTEMS; GENETICS; REVEALS; TARGETS; GENES; TOOLS;

D O I：

10.1093/nar/gkx1042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR'smain functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of> 300 human ageing-related genes and a dataset with > 2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring > 4000 species; (iii) the GenDR database with > 200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with > 500 entries; (v) the DrugAge database with > 400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with > 200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGRis freely available online (http://genomics.senescence.info/).

引用

页码：D1083 / D1090

页数：8

共 47 条

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