Morphine sensitization increases the extracellular level of glutamate in CA1 of rat hippocampus via μ-opioid receptor

被引：23

作者：

Farahmandfar, Maryam ^{[1
,2
]}

Karimian, Seyed Morteza ^{[2
]}

Zarrindast, Mohammad-Reza ^{[3
]}

Kadivar, Mehdi ^{[4
]}

Afrouzi, Hossein ^{[5
]}

Naghdi, Nasser ^{[1
]}

机构：

[1] Pasteur Inst Iran, Dept Physiol & Pharmacol, Tehran 13164, Iran

[2] Univ Tehran Med Sci, Dept Physiol, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmacol, Tehran, Iran

[4] Pasteur Inst Iran, Dept Biochem, Tehran 13164, Iran

[5] Darou Pakhsh Pharmaceut Res Ctr, Tehran, Iran

来源：

NEUROSCIENCE LETTERS | 2011年 / 494卷 / 02期

关键词：

Morphine; Behavioral sensitization; Glutamate; Hippocampus; Microdialysis; INDUCED BEHAVIORAL SENSITIZATION; MESSENGER-RNA EXPRESSION; VENTRAL TEGMENTAL AREA; LONG-TERM POTENTIATION; NUCLEUS-ACCUMBENS; PRECIPITATED WITHDRAWAL; DOPAMINE RELEASE; INDUCED AMNESIA; ANA RATS; MICE;

D O I：

10.1016/j.neulet.2011.02.074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repeated administration of abuse drugs such as morphine elicits a progressive enhancement of drug-induced behavioral responses, a phenomenon termed behavioral sensitization. These changes in behavior may reflect plastic changes requiring regulation of glutamatergic system in the brain. In this study, we investigated the effect of morphine sensitization on extracellular glutamate concentration in the hippocampus, a brain region rich in glutamatergic neurons. Sensitization was induced by subcutaneous (s.c.) injection of morphine, once daily for 3 days followed by 5 days free of the opioid treatment. The results showed that extracellular glutamate concentration in the CM was decreased following administration of morphine in non-sensitized rats. However, morphine-induced behavioral sensitization significantly increased the extracellular glutamate concentration in this area. The enhancement of glutamate in morphine sensitized rats was prevented by administration of naloxone 30 min before each of three daily doses of morphine. These results suggest an adaptation of the glutamatergic neuronal transmission in the hippocampus after morphine sensitization and it is postulated that opioid receptors may play an important role in this effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 134

页数：5

共 39 条

[1] Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine [J].