An improved and practical synthesis of 5,5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2-(5H)-furanone (DFP-a selective inhibitor of cyclooxygenase-2)

被引：44

作者：

Padakanti, S ^{[1
]}

Pal, M ^{[1
]}

Yeleswarapu, KR ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Chem Discovery Res, Hyderabad 500050, Andhra Pradesh, India

来源：

TETRAHEDRON | 2003年 / 59卷 / 40期

关键词：

anti-inflammatory agents; furanones; 2-isopropoxyacetic acid;

D O I：

10.1016/j.tet.2003.08.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DFP, a highly selective and potent COX-2 inhibitor, has been synthesized by a modified approach. Three modifications of the existing method enabled us to prepare DFP in good quantity. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7915 / 7920

页数：6

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