Forces on adhesive contacts affect cell function

被引：226
|
作者：
Galbraith, CG [1 ]
Sheetz, MP [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0955-0674(98)80030-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.
引用
收藏
页码：566 / 571
页数：6
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