Palladium-Catalyzed Cross-Coupling between 7-Azaindoles and Reformatsky Reagents

被引：9

作者：

Barl, Nadja M. ^{[1
]}

Malakhov, Vladimir ^{[1
]}

Mathes, Christian ^{[2
]}

Lustenberger, Philipp ^{[2
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

[2] Novartis Pharma AG, CH-4056 Basel, Switzerland

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 05期

基金：

欧洲研究理事会;

关键词：

azaindole; Reformatsky reagents; metalation; palladium; cross-coupling; FUNCTIONALIZED ORGANOZINC REAGENTS; INHIBITORY-ACTIVITY; CARBON-DIOXIDE; ZINCATION; REACTIVITY; AZAINDOLES; ALDEHYDES; HALIDES; KETONES; POTENT;

D O I：

10.1055/s-0034-1379459

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields.

引用

页码：692 / 700

页数：9

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