Pyrroles and Indolizidines from Deprotonated α-(Alkylideneamino)nitriles

被引：11

作者：

Schaefer, Ines ^{[1
,2
]}

Opatz, Till ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] Univ Hamburg, Dept Chem, D-20146 Hamburg, Germany

来源：

SYNTHESIS-STUTTGART | 2011年 / 11期

关键词：

heterocycles; carbanions; pyrroles; Umpolung; Michael addition; ONE-POT SYNTHESIS; POLYSUBSTITUTED PYRROLIDINES; AZOMETHINE YLIDES; 2-AZAALLYL ANIONS; SYNTHETIC EQUIVALENTS; ALPHA-AMINONITRILES; CYCLOADDITIONS; KETONES; ESTERS; N-(1-CYANOALKYL)IMINES;

D O I：

10.1055/s-0030-1260415

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Their ready availability from simple starting materials in only two synthetic steps and their versatility as building blocks for the construction of highly substituted amines and N-heterocycles renders alpha-(alkylideneamino)nitriles useful synthetic intermediates. Herein, short syntheses of tri- and tetrasubstituted pyrroles including the northern half of the HMG-CoA reductase inhibitor atorvastatin as well as an access to 3-substituted indolizidines will be described.

引用

页码：1691 / 1704

页数：14

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