New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

被引：33

作者：

Caliceti, Cristiana ^{[1
,2
,3
]}

Punzo, Angela ^{[4
]}

Silla, Alessia ^{[5
]}

Simoni, Patrizia ^{[6
]}

Roda, Giulia ^{[3
]}

Hrelia, Silvana ^{[5
]}

机构：

[1] Univ Bologna, Dept Biomed & Neuromotor Sci, Alma Mater Studiorum, I-40126 Bologna, Italy

[2] Univ Bologna, Interdept Ctr Renewable Sources Environm Sea & En, Alma Mater Studiorum, I-40126 Bologna, Italy

[3] Biostruct & Biosyst Natl Inst INBB, I-00136 Rome, Italy

[4] Univ Bologna, Dept Chem Giacomo Ciamician, Alma Mater Studiorum, I-40126 Bologna, Italy

[5] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-40126 Bologna, Italy

[6] Univ Bologna, Dept Med & Surg Sci, Alma Mater Studiorum, I-40138 Bologna, Italy

来源：

NUTRIENTS | 2022年 / 14卷 / 14期

关键词：

colorectal cancer; bile acids; FXR; VDR; PXR; SXR; TGR5; HUMAN COLON-CANCER; NF-KAPPA-B; VITAMIN-D-RECEPTOR; EPITHELIAL-CELL PROLIFERATION; FARNESOID X RECEPTOR; NUCLEAR RECEPTOR; ENTEROHEPATIC CIRCULATION; MEMBRANE-RECEPTOR; LITHOCHOLIC ACID; GUT MICROBIOTA;

D O I：

10.3390/nu14142964

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence.

引用

页数：28

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