Nitric oxide synthase containing periglomerular cells are GABAergic in the rat olfactory bulb

被引：30

作者：

Crespo, C ^{[1
]}

Gracia-Llanes, FJ ^{[1
]}

Blasco-Ibáñez, JM ^{[1
]}

Gutièrrez-Mecinas, M ^{[1
]}

Marqués-Marí, AI ^{[1
]}

Martínez-Guijarro, FJ ^{[1
]}

机构：

[1] Univ Valencia, Fac Ciencias Biol, Dept Biol Celular, E-46100 Burjassot, Spain

来源：

NEUROSCIENCE LETTERS | 2003年 / 349卷 / 03期

关键词：

GABA; NADPH-diaphorase; nitric oxide; olfaction; olfactory glomeruli; periglomerular cells;

D O I：

10.1016/S0304-3940(03)00819-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the olfactory glomeruli of the rat olfactory bulb, there is a population of periglomerular cells (PG) that contains the neuronal isoform of the nitric oxide synthase (nNOS). To date, these PG have not been characterized neurochemically and it has not been determined whether they are type 1 (GABAergic PG that receive synaptic contacts from the olfactory axons) or type 2 PG (non-GABAergic PG that do not receive synapses from the olfactory axons). Combining pre-embedding NADPH-diaphorase histochemistry and post-embedding immunoperoxidase detection of GABA, we demonstrate that nNOS-containing PG are GABAergic and therefore, belong to the type 1 PG. The possible actions of nitric oxide in the olfactory glomeruli are discussed. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：151 / 154

页数：4

相关论文

共 21 条

[1] CALBINDIN-D-28K AND NADPH-DIAPHORASE ACTIVITY ARE LOCALIZED IN DIFFERENT POPULATIONS OF PERIGLOMERULAR CELLS IN THE RAT OLFACTORY-BULB [J].

ALONSO, JR ;

AREVALO, R ;

PORTEROS, A ;

BRINON, JG ;

LARA, J ;

AIJON, J .

JOURNAL OF CHEMICAL NEUROANATOMY, 1993, 6 (01) :1-6

[2]

ALONSO JR, 1995, NEUROSCIENCE PROTOCO, P1

[3] Calretinin- and parvalbumin-immunoreactive neurons in the rat main olfactory bulb do not express NADPH-diaphorase activity [J].

Brinon, JG ;

Alonso, JR ;

GarciaOjeda, E ;

Crespo, C ;

Arevalo, R ;

Aijon, J .

JOURNAL OF CHEMICAL NEUROANATOMY, 1997, 13 (04) :253-264

[4] NMDA-induced acetylcholine release in mouse striatum: role of NO synthase isoforms [J].

Buchholzer, ML ;

Klein, J .

JOURNAL OF NEUROCHEMISTRY, 2002, 82 (06) :1558-1560

[5] Subcellular localization of m2 muscarinic receptors in GABAergic interneurons of the olfactory bulb [J].

Crespo, C ;

Blasco-Ibáñez, JM ;

Briñón, JG ;

Alonso, JR ;

Domínguez, MI ;

Martínez-Guijarro, FJ .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (11) :3963-3974

[6] NADPH DIAPHORASE STAINING SUGGESTS LOCALIZATION OF NITRIC-OXIDE SYNTHASE WITHIN MATURE VERTEBRATE OLFACTORY NEURONS [J].

DELLACORTE, C ;

KALINOSKI, DL ;

HUQUE, T ;

WYSOCKI, L ;

RESTREPO, D .

NEUROSCIENCE, 1995, 66 (01) :215-225

[7] Release patterns of excitatory inhibitory amino acids within the hypothalamic supraoptic nucleus in response to direct nitric oxide administration during forced swimming in rats [J].

Engelmann, M ;

Wolf, G ;

Horn, TFW .

NEUROSCIENCE LETTERS, 2002, 324 (03) :252-254

[8] Dopamine d2 receptor-mediated presynaptic inhibition of olfactory nerve terminals [J].

Ennis, M ;

Zhou, FM ;

Ciombor, KJ ;

Aroniadou-Anderjaska, V ;

Hayar, A ;

Borrelli, E ;

Zimmer, LA ;

Margolis, F ;

Shipley, MT .

JOURNAL OF NEUROPHYSIOLOGY, 2001, 86 (06) :2986-2997

[9] THE NO HYPOTHESIS - POSSIBLE EFFECTS OF A SHORT-LIVED, RAPIDLY DIFFUSIBLE SIGNAL IN THE DEVELOPMENT AND FUNCTION OF THE NERVOUS-SYSTEM [J].

GALLY, JA ;

MONTAGUE, PR ;

REEKE, GN ;

EDELMAN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3547-3551

[10]

Hopkins DA, 1996, J COMP NEUROL, V375, P641