Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes

被引：41

作者：

Jia, Xiangqing ^{[1
]}

Zhang, Ziyan ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Texas Dallas, Dept Chem & Biochem, Richardson, TX 75080 USA

来源：

ACS CATALYSIS | 2021年 / 11卷 / 21期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

difunctionalization; isocyanide; radical; palladium; light-induced; C-H ALKYLATION; CARBENE; DICARBOFUNCTIONALIZATION; ISOCYANIDES; TERTIARY; OLEFINS;

D O I：

10.1021/acscatal.1c04183

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeds via the in situ formation of a reactive ketenimine intermediate, allows for a rapid construction of a broad range of valuable amides and nitriles from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated.

引用

页码：13217 / 13222

页数：6

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