Nationalities universities are important composition of the system of high education in some countries. In the 21st century, the development of nationalities universities is faced with good fortune and challenge. On the foundation of analysis the location and major content, this paper presents an evaluation of strategic option of development for nationalities universities adapting the external environment; applying the thought of comparative advantage theory in analyzing the rationality of strategic option of development for Nationalities Universities, and the contents of evaluation include location, subject construction, talent training, scientific research, serve society and so on.